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1. WO2020138868 - TYPE 1 INTERFERON NEUTRALIZING FC-FUSION PROTEIN AND USE THEREOF

Publication Number WO/2020/138868
Publication Date 02.07.2020
International Application No. PCT/KR2019/018233
International Filing Date 20.12.2019
IPC
C07K 14/715 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
715for cytokines; for lymphokines; for interferons
C07K 16/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
CPC
C07K 14/715
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
715for cytokines; for lymphokines; for interferons
C07K 16/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
Applicants
  • 서울대학교산학협력단 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR]/[KR]
  • (재)록원바이오융합연구재단 LOGONE BIO CONVERGENCE RESEARCH FOUNDATION [KR]/[KR]
Inventors
  • 신영기 SHIN, Young Kee
  • 이세형 LEE, Sae Hyung
  • 김성수 KIM, Sung Su
Agents
  • 이희숙 LEE, Hee Sook
Priority Data
10-2018-016880124.12.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) TYPE 1 INTERFERON NEUTRALIZING FC-FUSION PROTEIN AND USE THEREOF
(FR) PROTÉINE DE FUSION FC NEUTRALISANT UN INTERFÉRON DE TYPE 1 ET SON UTILISATION
(KO) 타입 1 인터페론 중화 FC-융합 단백질 및 이의 용도
Abstract
(EN)
The present invention relates to a type 1 interferon neutralizing FC-fusion protein and a use thereof and, more specifically, to: a dimer-type polypeptide to which a monomer comprising an interferon receptor fragment or an antibody Fc fragment is bound; a preparation method therefor; and a pharmaceutical composition comprising same. The type 1 interferon neutralizing FC-fusion protein of the present invention blocks binding between type 1 interferon and an interferon receptor, and has an excellent ability of inhibiting the signaling and biological activities of interferon, thereby enabling diseases mediated by a type 1 interferon to be effectively treated.
(FR)
La présente invention concerne une protéine de fusion FC neutralisant un interféron de type 1 et son utilisation et, plus particulièrement : un polypeptide de type dimère auquel est lié un monomère comprenant un fragment du récepteur de l'interféron ou un fragment fc d'anticorps ; un procédé de préparation associé ; et une composition pharmaceutique le comprenant. La protéine de fusion FC neutralisant l'interféron de type 1 selon la présente invention bloque la liaison entre l'interféron de type 1 et un récepteur d'interféron, et a une excellente aptitude à inhiber la signalisation et les activités biologiques de l'interféron, ce qui permet de traiter de manière efficace des maladies à médiation par un interféron de type 1.
(KO)
본 발명은 타입 1 인터페론 중화 Fc-융합 단백질 및 이의 용도에 관한 것으로, 보다 상세하게는 인터페론 수용체 단편 또는 항체 Fc 단편을 포함하는 모노머(monomer)가 결합된 다이머(dimer)형 폴리펩티드 및 그의 제조방법, 그를 포함하는 약학적 조성물에 관한 것이다. 본 발명의 타입 1 인터페론 중화 Fc-융합 단백질은 타입 1 인터페론과 인터페론 수용체의 결합을 차단하면서, 인터페론의 신호전달 및 생물학적 활성을 억제능이 우수하여 타입 1 인터페론이 매개하는 질환을 효과적으로 치료할 수 있다.
Also published as
Latest bibliographic data on file with the International Bureau