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1. WO2020138805 - COMPOSITION COMPRISING RADIOACTIVE METAL AND EUROPIUM FOR PHOTODYNAMIC THERAPY

Publication Number WO/2020/138805
Publication Date 02.07.2020
International Application No. PCT/KR2019/017816
International Filing Date 16.12.2019
IPC
A61K 41/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 51/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
12characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
A61K 47/54 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
CPC
A61K 2121/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2121Preparations for use in therapy
A61K 2123/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2123Preparations for testing in vivo
A61K 41/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
A61K 41/0057
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
A61K 47/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
A61K 47/542
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
542Carboxylic acids, e.g. a fatty acid or an amino acid
Applicants
  • 서울대학교산학협력단 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR]/[KR]
Inventors
  • 임형준 IM, Hyung Jun
  • 이우승 LEE, Woo Seung
  • 전미연 JEON, Mi Yeon
  • 최진영 CHOI, Jin Yeong
  • 오치우 OH, Chi Woo
Agents
  • 특허법인리채 LEECHAE INTELLECTUAL PROPERTY
Priority Data
10-2018-017305628.12.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION COMPRISING RADIOACTIVE METAL AND EUROPIUM FOR PHOTODYNAMIC THERAPY
(FR) COMPOSITION COMPRENANT UN MÉTAL RADIOACTIF ET DE L'EUROPIUM POUR UNE THÉRAPIE PHOTODYNAMIQUE
(KO) 방사성 금속 및 유로피움을 포함하는 광역동 요법용 조성물
Abstract
(EN)
A composition of the present invention comprises: a radio-labelled liposome encapsulating an Eu-DTPA complex and Victoria-blue BO therein; and a radioactive metal and as such, has high stability and excellent ability to generate reactive oxygen species in vivo. Therefore, the composition can exhibit excellent circulatory potential and target performance when used in photodynamic therapy.
(FR)
Une composition de la présente invention comprend : un liposome radio-marqué encapsulant un complexe Eu-DTPA et bleu Victoria BO à l'intérieur de celui-ci; et un métal radioactif et, de ce fait, présente une stabilité élevée et une excellente aptitude à générer in vivo des espèces réactives de l'oxygène. Par conséquent, la composition peut présenter un excellent potentiel circulatoire et une excellente performance cible lorsqu'elle est utilisée en thérapie photodynamique.
(KO)
본 발명의 조성물은 Eu-DTPA 복합체 및 Victoria-blue BO를 담지한 방사성 표지 리포좀; 및 방사성 금속을 포함함으로써, 생체 내 높은 안정도와, 우수한 활성산소 발생능력을 가지고 있다. 따라서, 광역동 요법에 사용시 우수한 순환능과 표적능을 발휘할 수 있다.
Also published as
Latest bibliographic data on file with the International Bureau