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1. WO2020138713 - EBP50-CONTAINING COMPOSITION FOR TREATING DAMAGED PERIPHERAL NERVES

Publication Number WO/2020/138713
Publication Date 02.07.2020
International Application No. PCT/KR2019/015416
International Filing Date 13.11.2019
IPC
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61P 25/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
CPC
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
Applicants
  • 가톨릭관동대학교산학협력단 CATHOLIC KWANDONG UNIVERSITY INDUSTRY COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 송견지 SONG, Gyun Jee
  • 굽타디퍽 프르사드 GUPTA, Deepak Prasad
Agents
  • 특허법인지담 JIDAM IP LAW FIRM
Priority Data
10-2018-017012427.12.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) EBP50-CONTAINING COMPOSITION FOR TREATING DAMAGED PERIPHERAL NERVES
(FR) COMPOSITION CONTENANT DE L'EBP50 PERMETTANT LE TRAITEMENT DE NERFS PÉRIPHÉRIQUES LÉSÉS
(KO) EBP50을 포함하는 말초신경손상 치료용 조성물
Abstract
(EN)
The present invention relates to the therapeutic effects of EBP50 gene on damaged peripheral nerves and, more specifically, discloses damage-treatment accelerating effects of EBP50 in the peripheral nerve system, and a novel EBP50-containing vector and composition for treating damaged peripheral nerves. The vector and the composition comprising the vector according to an embodiment of the present invention enable EBP50 to be expressed specifically in Schwann cells in which EBP50 functions. EBP50 introduced into Schwann cells in such a way can accelerate the recovery of sensory functions as well as motor functions that have deteriorated due to damage to the peripheral nerves, promote re-myelination of nerve cells, and help the recovery to be more complete.
(FR)
La présente invention concerne les effets thérapeutiques du gène EBP50 sur les nerfs périphériques lésés et, plus précisément, concerne des effets d'accélération du traitement de lésions de EBP50 dans le système nerveux périphérique, et un nouveau vecteur contenant de l'EBP50 et une composition destinée à traiter des nerfs périphériques lésés. Le vecteur et la composition comprenant le vecteur selon un mode de réalisation de la présente invention permettent d'exprimer EBP50 spécifiquement dans les cellules de Schwann dans lesquelles fonctionne l'EBP50. L'EBP50 introduit dans les cellules de Schwann de cette manière permet d'accélérer la récupération de fonctions sensorielles ainsi que de fonctions motrices qui ont été détériorées en raison d'une lésion des nerfs périphériques, de favoriser la re-myélinisation des cellules nerveuses, et d'aider la récupération à être plus complète.
(KO)
본 발명은 EBP50 유전자의 말초신경손상 치료 효과에 관한 것으로, 더욱 상세하게는 말초신경계에서 EBP50이 가지는 손상의 치료 가속화 효능과, EBP50을 포함하는 신규한 말초신경손상 치료용 벡터 및 조성물을 개시한다. 본 발명의 실시예에 따른 벡터 및 상기 벡터를 포함하는 조성물은 EBP50이 기능하는 세포인 슈반세포에 특이적으로 EBP50이 발현될 수 있도록 한다. 이렇게 슈반세포에 도입된 EBP50은 말초신경 손상에 따라 저하된 운동기능은 물론 감각기능의 회복을 가속화하고 신경세포의 재수초화를 촉진하며 상기 회복이 좀더 온전하도록 할 수 있다.
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