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1. WO2020138570 - NOVEL RUTHENIUM COMPLEX COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER

Publication Number WO/2020/138570
Publication Date 02.07.2020
International Application No. PCT/KR2018/016898
International Filing Date 28.12.2018
IPC
C07F 15/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
A61K 31/555 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
555containing heavy metals, e.g. hemin, hematin, melarsoprol
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/555
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
555containing heavy metals, e.g. hemin, hematin, melarsoprol
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07F 15/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
Applicants
  • 서울대학교 산학협력단 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR]/[KR]
Inventors
  • 송준명 SONG, Joon Myong
Agents
  • 이원희 LEE, Won Hee
Priority Data
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) NOVEL RUTHENIUM COMPLEX COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER
(FR) NOUVEAU COMPOSÉ COMPLEXE DE RUTHÉNIUM, SON PROCÉDÉ DE PRÉPARATION ET COMPOSITION PHARMACEUTIQUE LE CONTENANT EN TANT QUE PRINCIPE ACTIF POUR PRÉVENIR OU TRAITER LE CANCER
(KO) 신규 루테늄 착화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
Abstract
(EN)
The present invention relates to a novel ruthenium complex compound, a preparation method therefor, and a pharmaceutical composition comprising same as an active ingredient for prevention or treatment of cancer. A novel Ru complex compound according to the present invention exhibits not only an excellent killing effect on cancer cells, but also can outstandingly inhibit resistance mechanisms of cancer stem cells. Thus, the complex compound can be effectively used as an active ingredient in a pharmaceutical composition for prevention or treatment of cancer or a composition for inhibiting resistance to anticancer agents, and can be used in combination of other chemotherapeutic agents in a pharmaceutical composition for prevention or treatment of cancer, which solves conventional problems of resistance to anticancer agents.
(FR)
La présente invention concerne un nouveau composé complexe de ruthénium, son procédé de préparation et une composition pharmaceutique le comprenant en tant que principe actif pour prévenir ou traiter le cancer. Le nouveau composé complexe de Ru selon la présente invention a non seulement un excellent effet de destruction sur des cellules cancéreuses, mais peut également inhiber de manière remarquable les mécanismes de résistance des cellules souches cancéreuses. Ainsi, le composé complexe peut être utilisé de manière efficace en tant que principe actif dans une composition pharmaceutique pour la prévention ou le traitement du cancer ou une composition pour l'inhibition de la résistance à des agents anticancéreux, et peut être utilisé en combinaison avec d'autres agents chimiothérapeutiques dans une composition pharmaceutique pour la prévention ou le traitement du cancer ; l'invention peut ainsi résoudre des problèmes classiques se liant à la résistance à des agents anticancéreux.
(KO)
본 발명은 신규 루테늄 착화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 신규 Ru 착화합물은 암 세포에 대하여 우수한 사멸 효과를 나타낼 뿐 아니라, 암줄기세포의 내성 발생 기작을 우수하게 저해할 수 있는 바, 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물, 또는 항암제 내성 억제용 조성물, 및 이를 여타의 화학 요법제와 병용하여 기존의 항암제 내성 문제가 개선된 암의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.
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