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1. WO2020138510 - ACQUISITION OF L1CAM-POSITIVE CELLS FROM CEREBRAL CORTEX CELLS AND USE THEREOF AS CELL PREPARATION

Publication Number WO/2020/138510
Publication Date 02.07.2020
International Application No. PCT/JP2019/051652
International Filing Date 27.12.2019
IPC
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
A61P 25/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
CPC
A61K 35/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
A61K 35/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
Applicants
  • 国立大学法人京都大学 KYOTO UNIVERSITY [JP]/[JP]
Inventors
  • ▲高▼橋 淳 TAKAHASHI, Jun
  • 佐俣 文平 SAMATA, Bumpei
  • 佐野 徳隆 SANO, Noritaka
Agents
  • 特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES
Priority Data
2018-24796028.12.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ACQUISITION OF L1CAM-POSITIVE CELLS FROM CEREBRAL CORTEX CELLS AND USE THEREOF AS CELL PREPARATION
(FR) ACQUISITION DE CELLULES POSITIVES À L1CAM À PARTIR DE CELLULES DE CORTEX CÉRÉBRAL ET UTILISATION CORRESPONDANTE EN TANT QUE PRÉPARATION CELLULAIRE
(JA) 大脳皮質細胞からのL1CAM陽性細胞の取得および細胞製剤としてのその使用
Abstract
(EN)
This application provides: a method that is for acquiring L1CAM-positive cells and that comprises isolating and collecting L1CAM-positive cells from cerebral cortex cells derived from a mammal, such as human, using the cell surface marker L1CAM as an indicator; L1CAM-positive cells obtained using the method; a cell preparation that contains these cells and that is for treating a cerebral cortex disorder and/or a cerebral cortex spinal tract disorder; and a method that is for treating a cerebral cortex disorder and/or a cerebral cortex spinal tract disorder and that comprises administering a cell preparation to the cerebral cortex and/or cerebral cortex spinal tract of a subject having a cerebral cortex disorder and/or a cerebral cortex spinal tract disorder.
(FR)
La présente invention concerne : un procédé qui est destiné à acquérir des cellules positives à L1CAM et qui comprend l'isolement et la collecte de cellules positives à L1CAM à partir de cellules de cortex cérébral issues d'un mammifère, tel qu'un être humain, à l'aide du marqueur de surface cellulaire L1CAM en tant qu'indicateur ; des cellules positives à L1CAM obtenues à l'aide du procédé ; une préparation cellulaire qui contient ces cellules et qui est destinée à traiter un trouble du cortex cérébral et/ou un trouble du tractus rachidien du cortex cérébral ; et un procédé qui est destiné à traiter un trouble du cortex cérébral et/ou un trouble du tractus rachidien du cortex cérébral et qui comprend l'administration d'une préparation cellulaire au cortex cérébral et/ou au tractus spinal du cortex cérébral d'un sujet atteint d'un trouble du cortex cérébral et/ou d'un trouble du tractus rachidien du cortex cérébral.
(JA)
この出願は、ヒトなどの哺乳動物由来の大脳皮質細胞から細胞表面マーカーL1CAMを指標にしてL1CAM陽性細胞を分離し回収することを含むL1CAM陽性細胞を取得する方法、この方法によって得られるL1CAM陽性細胞、この細胞を含む大脳皮質障害および/または大脳皮質脊髄路障害を治療するための細胞製剤、ならびに、大脳皮質障害および/または大脳皮質脊髄路障害をもつ被験体の大脳皮質および/または大脳皮質脊髄路に細胞製剤を投与することを含む大脳皮質障害および/または大脳皮質脊髄路障害の治療方法を提供する。
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