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1. WO2020138487 - BISPECIFIC ANTIBODY BINDING TO TfR

Publication Number WO/2020/138487
Publication Date 02.07.2020
International Application No. PCT/JP2019/051594
International Filing Date 27.12.2019
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12P 21/02 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
A61K 47/64 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/65
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
65Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
Applicants
  • 協和キリン株式会社 KYOWA KIRIN CO., LTD. [JP]/[JP]
Inventors
  • 三田村 圭祐 MITAMURA Keisuke
  • 中野 了輔 NAKANO Ryosuke
  • 甲斐 正之 KAI Masayuki
  • 高橋 信明 TAKAHASHI Nobuaki
Agents
  • 特許業務法人栄光特許事務所 Eikoh Patent Firm, P.C.
Priority Data
2018-24833428.12.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) BISPECIFIC ANTIBODY BINDING TO TfR
(FR) ANTICORPS BISPÉCIFIQUE LIÉ AU RÉCEPTEUR DE LA TRANSFERRINE (TfR)
(JA) TfRに結合するバイスペシフィック抗体
Abstract
(EN)
The present invention pertains to: a bispecific antibody wherein the N-terminal polypeptide binds to the IgG portion that binds to TfR; a fragment of the bispecific antibody; a DNA encoding the bispecific antibody or the bispecific antibody fragment; a vector containing the DNA; a hybridoma and a transformant strain producing the bispecific antibody or the bispecific antibody fragment; a method for producing the bispecific antibody or the bispecific antibody fragment; a therapeutic and diagnostic drug comprising the bispecific antibody or the bispecific antibody fragment; a therapeutic and diagnostic method using the bispecific antibody or the bispecific antibody fragment; and a detection or assay reagent comprising the bispecific antibody or the bispecific antibody fragment.
(FR)
L'invention concerne un anticorps bispécifique auquel est lié un polypeptide côté N-terminal dans une portion IgG liée au TfR, un fragment de cet anticorps bispécifique, un ADN codant cet anticorps bispécifique ou ce fragment d'anticorps bispécifique, un vecteur contenant cet ADN, un hybridome ou un transformé générant cet anticorps bispécifique ou ce fragment d'anticorps bispécifique, un procédé de fabrication de cet anticorps bispécifique ou de ce fragment d'anticorps bispécifique, un agent de traitement ou de diagnostic contenant cet anticorps bispécifique ou ce fragment d'anticorps bispécifique, un procédé de traitement ou de diagnostic mettant en œuvre cet anticorps bispécifique ou ce fragment d'anticorps bispécifique, et un réactif de détection ou de mesure contenant cet anticorps bispécifique ou ce fragment d'anticorps bispécifique.
(JA)
本発明は、TfRに結合するIgG部分にN末端側ポリペプチドが結合したバイスペシフィック抗体、該バイスペシフィック抗体断片、該バイスペシフィック抗体または該バイスペシフィック抗体断片をコードするDNA、該DNAを含むベクター、該バイスペシフィック抗体または該バイスペシフィック抗体断片を生産するハイブリドーマおよび形質転換株、該バイスペシフィック抗体または該バイスペシフィック抗体断片の製造方法、該バイスペシフィック抗体または該バイスペシフィック抗体断片を含む治療および診断薬、該バイスペシフィック抗体または該バイスペシフィック抗体断片を用いる治療および診断方法、ならびに該バイスペシフィック抗体または該バイスペシフィック抗体断片を含む検出または測定試薬に関する。
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