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1. WO2020138346 - SOFT INTRAOCULAR LENS MATERIAL AND SOFT INTRAOCULAR LENS

Publication Number WO/2020/138346
Publication Date 02.07.2020
International Application No. PCT/JP2019/051262
International Filing Date 26.12.2019
IPC
C08F 220/18 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
220Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide, or nitrile thereof
02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
10Esters
12of monohydric alcohols or phenols
16of phenols or of alcohols containing two or more carbon atoms
18with acrylic or methacrylic acids
C08F 220/20 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
220Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide, or nitrile thereof
02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
10Esters
20of polyhydric alcohols or phenols
C08F 220/26 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
220Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide, or nitrile thereof
02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
10Esters
26Esters containing oxygen in addition to the carboxy oxygen
A61F 2/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
14Eye parts, e.g. lenses, corneal implants; Artificial eyes
16Intraocular lenses
A61L 27/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
16obtained by reactions only involving carbon-to-carbon unsaturated bonds
CPC
A61F 2/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
14Eye parts, e.g. lenses, corneal implants; ; Implanting instruments specially adapted therefor; Artificial eyes
16Intraocular lenses
A61L 27/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
14Macromolecular materials
16obtained by reactions only involving carbon-to-carbon unsaturated bonds
C08F 220/18
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
220Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
10Esters
12of monohydric alcohols or phenols
16of phenols or of alcohols containing two or more carbon atoms
18with acrylic or methacrylic acids
C08F 220/20
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
220Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
10Esters
20of polyhydric alcohols or phenols ; , e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
C08F 220/26
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
220Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
10Esters
26Esters containing oxygen in addition to the carboxy oxygen
Applicants
  • 株式会社ニデック NIDEK CO., LTD. [JP]/[JP]
Inventors
  • 豊田 隆廣 TOYODA, Takahiro
  • 村瀬 響子 MURASE, Kyoko
Agents
  • 安部 誠 ABE, Makoto
Priority Data
PCT/JP2018/04861028.12.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) SOFT INTRAOCULAR LENS MATERIAL AND SOFT INTRAOCULAR LENS
(FR) MATÉRIAU POUR LENTILLE INTRAOCULAIRE SOUPLE ET LENTILLE INTRAOCULAIRE SOUPLE
(JA) 軟質眼内レンズ材料および軟質眼内レンズ
Abstract
(EN)
Provided are a soft intraocular lens material and a soft intraocular lens, which achieve flexibility and shape recoverability as well as reduction of glistening. The soft intraocular lens material is obtained through polymerization of polymerizable components having polymerizability, the polymerizable components including: an aromatic ring-containing methacrylate (A); an alkoxy group-containing acrylate (B); a hydroxy group-containing acrylate (C); and a cross-linkable (meth)acrylate (D). With respect to 100 parts by mass of the polymerizable components, the proportion of the alkoxy group-containing acrylate (B) is 30 parts by mass or more. The proportion of the aromatic ring-containing methacrylate (A) preferably 40-52 parts by mass. The proportion of the alkoxy group-containing acrylate (B) is preferably 35-46 parts by mass.
(FR)
L'invention concerne un matériau pour lentille intraoculaire souple et une lentille intraoculaire souple, qui apportent flexibilité et récupération de forme tout en offrant une baisse de brillance. Le matériau pour lentille intraoculaire souple est obtenu par polymérisation de constituants polymérisables ayant une aptitude à être polymérisés, les constituants polymérisables comprenant : un méthacrylate contenant un cycle aromatique (A); un acrylate contenant un groupe alcoxy (B); un acrylate contenant un groupe hydroxy (C); et un (méth)acrylate réticulable (D). Par rapport à 100 parties en masse des constituants polymérisables, la proportion de l'acrylate contenant un groupe alcoxy (B) est de 30 parties en masse ou plus. La proportion du méthacrylate contenant un cycle aromatique (A) est de préférence comprise entre 40 et 52 parties en masse. La proportion de l'acrylate contenant un groupe alcoxy (B) est de préférence comprise entre 35 et 46 parties en masse.
(JA)
柔軟性および形状回復性と、グリスニングの低減とが両立された軟質眼内レンズ材料と軟質眼内レンズを提供する。軟質眼内レンズ材料は、重合性を有する重合成分を重合させてなり、前記重合成分は、芳香族環含有メタクリレート(A)と、アルコキシ基含有アクリレート(B)と、ヒドロキシ基含有アクリレート(C)と、架橋性(メタ)アクリレート(D)と、を含む。重合成分を100質量部としたとき、アルコキシ基含有アクリレート(B)の割合は、30質量部以上である。また、芳香族環含有メタクリレート(A)は、40質量部以上52質量部以下であるとよい。アルコキシ基含有アクリレート(B)は、35質量部以上46質量部以下であるとよい。
Also published as
EP2019903132
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