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1. WO2020138282 - EICOSAPENTAENOIC ACID ALKYL ESTER-CONTAINING COMPOSITION AND METHOD FOR PRODUCING SAME

Publication Number WO/2020/138282
Publication Date 02.07.2020
International Application No. PCT/JP2019/051107
International Filing Date 26.12.2019
IPC
C07C 69/587 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
52Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
587Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
C11B 3/12 2006.1
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
3Refining fats or fatty oils
12by distillation
CPC
C07C 69/587
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
52Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
587Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
C11B 3/12
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
3Refining fats or fatty oils
12by distillation
Applicants
  • 日清ファルマ株式会社 NISSHIN PHARMA INC. [JP]/[JP]
Inventors
  • 後藤 一郎 GOTO, Ichiro
  • 原田 昌卓 HARATA, Masataka
  • 野中 信吾 NONAKA, Shingo
Agents
  • 特許業務法人アルガ特許事務所 THE PATENT CORPORATE BODY ARUGA PATENT OFFICE
Priority Data
2018-24241726.12.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) EICOSAPENTAENOIC ACID ALKYL ESTER-CONTAINING COMPOSITION AND METHOD FOR PRODUCING SAME
(FR) COMPOSITION CONTENANT UN ESTER ALKYLIQUE D'ACIDE EICOSAPENTAÉNOÏQUE ET SON PROCÉDÉ DE PRODUCTION
(JA) エイコサペンタエン酸アルキルエステル含有組成物及びその製造方法
Abstract
(EN)
The present invention provides an eicosapentaenoic acid-containing composition having high concentration and high purity. A method for producing an eicosapentaenoic acid alkyl ester-containing composition, which comprises (1) a process wherein a starting material oil containing an eicosapentaenoic acid alkyl ester is brought into contact with an aqueous solution containing a silver salt, and subsequently an aqueous layer is recovered, (2) a process wherein an organic solvent is added to the aqueous layer, and subsequently an organic solvent layer is recovered, and (3) a process wherein the organic solvent layer is subjected to vacuum distillation at a temperature of 180-188°C at a column top vacuum degree of 0.7 Pa or less, thereby recovering the eicosapentaenoic acid alkyl ester from the organic solvent layer.
(FR)
La présente invention concerne une composition contenant de l'acide eicosapentaénoïque ayant une concentration élevée et une haute élevée. L'invention concerne également un procédé de production d'une composition contenant un ester alkylique d'acide eicosapentaénoïque, comprenant (1) un procédé consistant à mettre en contact une huile de matière première contenant un ester alkylique d'acide eicosapentaénoïque avec une solution aqueuse contenant un sel d'argent, puis récupérer une couche aqueuse, (2) un procédé consistant à ajouter un solvant organique à la couche aqueuse, puis récupérer une couche de solvant organique, et (3) un procédé consistant à soumettre la couche de solvant organique à une distillation sous vide à une température de 180 à 188 °C à un niveau de vide de sommet de colonne inférieur ou égal à 0,7 Pa, ce qui permet de récupérer l'ester alkylique d'acide eicosapentaénoïque à partir de la couche de solvant organique.
(JA)
高濃度かつ高純度なエイコサペンタエン酸含有組成物の提供。エイコサペンタエン酸アルキルエステル含有組成物の製造方法であって、(1)エイコサペンタエン酸アルキルエステルを含有する原料油を、銀塩を含む水溶液と接触させた後、水層を回収すること;(2)該水層に有機溶媒を添加した後、有機溶媒層を回収すること;及び、(3)該有機溶媒層を、温度180~188℃、塔頂真空度0.7Pa以下で真空蒸留して、該有機溶媒層からエイコサペンタエン酸アルキルエステルを回収すること、を含む方法。
Also published as
JP2020562404
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