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1. WO2020137975 - METHOD FOR PRODUCING XANTHOHUMOL-CONTAINING COMPOSITION

Publication Number WO/2020/137975
Publication Date 02.07.2020
International Application No. PCT/JP2019/050366
International Filing Date 23.12.2019
IPC
A61K 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61P 39/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
06Free radical scavengers or antioxidants
C07C 45/79 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
45Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
78Separation; Purification; Stabilisation; Use of additives
79by solid-liquid treatment; by chemisorption
C07C 49/84 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
49Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
76Ketones containing a keto group bound to a six-membered aromatic ring
84containing ether groups, groups, groups, or groups
A61K 36/185 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
A23L 33/105 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
CPC
A23L 33/105
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
A61K 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 36/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
A61P 39/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
06Free radical scavengers or antioxidants
C07C 45/79
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
78Separation; Purification; Stabilisation; Use of additives
79by solid-liquid treatment; by chemisorption
C07C 49/84
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
49Ketones; Ketenes; Dimeric ketenes
76Ketones containing a keto group bound to a six-membered aromatic ring
84containing ether groups, groups, groups, or groups
Applicants
  • サントリーホールディングス株式会社 SUNTORY HOLDINGS LIMITED [JP]/[JP]
Inventors
  • 秦 悠斗 HATA, Yuto
  • 吉井 孝彰 YOSHII, Takaaki
  • 高木 理沙 TAKAGI, Risa
  • 中原 光一 NAKAHARA, Koichi
Agents
  • 特許業務法人 安富国際特許事務所 YASUTOMI & ASSOCIATES
Priority Data
2018-24531727.12.2018JP
2019-12760809.07.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR PRODUCING XANTHOHUMOL-CONTAINING COMPOSITION
(FR) PROCÉDÉ DE FABRICATION D'UNE COMPOSITION CONTENANT DU XANTHOHUMOL
(JA) キサントフモールを含有する組成物の製造方法
Abstract
(EN)
The present invention relates to a method for producing a xanthohumol-containing composition, the method comprising the steps of: bringing a first mixture containing a hop-derived component containing xanthofumol and a first solvent containing water and a water miscible solvent into contact with polyvinylpolypyrrolidone to adsorb xanthofumol on the polyvinylpolypyrrolidone; washing the xanthofumol-adsorbed polyvinylpolypyrrolidone with a second solvent; and eluting xanthofumol with a third solvent from the polyvinylpolypyrrolidone to obtain a xanthofumol-containing eluate. The second solvent is an ethanol aqueous solution. The third solvent is an ethanol aqueous solution having a higher concentration than the second solvent or ethanol.
(FR)
La présente invention porte sur un procédé de production d'une composition contenant du xanthohumol, le procédé comprenant les étapes consistant à: mettre un premier mélange contenant un composant dérivé du houblon contenant du xanthofumol et un premier solvant contenant de l'eau et un solvant miscible dans l'eau en contact avec la polyvinylpolypyrrolidone pour adsorber le xanthofumol sur la polyvinylpolypyrrolidone ; laver la polyvinylpolypyrrolidone adsorbée par le xanthofumol avec un deuxième solvant ; et éluer le xanthofumol avec un troisième solvant de la polyvinylpolypyrrolidone pour obtenir un éluat contenant du xanthofumol. Le deuxième solvant est une solution aqueuse d'éthanol. Le troisième solvant est une solution aqueuse d'éthanol présentant une concentration plus élevée que le deuxième solvant ou l'éthanol.
(JA)
本発明は、キサントフモールを含むホップ由来成分と、水及び水混和性溶媒を含む第一の溶媒とを含む第一の混合物と、ポリビニルポリピロリドンとを接触させて、キサントフモールを上記ポリビニルポリピロリドンに吸着させる工程;キサントフモールを吸着したポリビニルポリピロリドンを、第二の溶媒で洗浄する工程;及び、上記ポリビニルポリピロリドンから、第三の溶媒によりキサントフモールを溶出させて、キサントフモールを含む溶出液を得る工程を含み、上記第二の溶媒はエタノール水溶液であり、上記第三の溶媒は、上記第二の溶媒よりも濃度が高いエタノール水溶液又はエタノールである、キサントフモールを含有する組成物の製造方法などに関する。
Also published as
JP2020563252
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