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1. WO2020137017 - WHITENING AGENT, HYALURONIC ACID PRODUCTION PROMOTER, COLLAGEN PRODUCTION PROMOTER, INTRACELLULAR ACTIVE OXYGEN SCAVENGER, IRRITATION MITIGATOR, WRINKLE-AMELIORATING AGENT, COMPLEX, COSMETIC AND EXTERNAL PREPARATION FOR SKIN

Publication Number WO/2020/137017
Publication Date 02.07.2020
International Application No. PCT/JP2019/035511
International Filing Date 10.09.2019
IPC
A61K 8/60 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
60Sugars; Derivatives thereof
A61K 31/23 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
A61K 31/661 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
661Phosphorus acids or esters thereof not having P-C bonds, e.g. fosfosal, dichlorvos, malathion
A61K 31/683 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
A61K 31/685 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
685one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A61K 31/704 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
704attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
CPC
A61K 31/23
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
A61K 31/661
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion ; or mevinphos
A61K 31/683
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
A61K 31/685
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
685one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A61K 31/704
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
704attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
A61K 8/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
60Sugars; Derivatives thereof
Applicants
  • 日本精化株式会社 NIPPON FINE CHEMICAL CO., LTD. [JP]/[JP]
Inventors
  • 小寺 啓貴 KOTERA, Hiroki
  • 仁木 洋子 NIKI, Yoko
  • 小山 美穂 KOYAMA, Miho
  • 勝間田 祐貴 KATSUMATA, Yuki
  • 橋本 明宏 HASHIMOTO, Akihiro
  • 遠藤 香凜 ENDO, Karin
  • 上田 剛士 UEDA, Takeshi
  • 大橋 幸浩 OHASHI, Yukihiro
Agents
  • 特許業務法人三枝国際特許事務所 SAEGUSA & PARTNERS
Priority Data
2018-24208026.12.2018JP
2019-07757316.04.2019JP
2019-09429120.05.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) WHITENING AGENT, HYALURONIC ACID PRODUCTION PROMOTER, COLLAGEN PRODUCTION PROMOTER, INTRACELLULAR ACTIVE OXYGEN SCAVENGER, IRRITATION MITIGATOR, WRINKLE-AMELIORATING AGENT, COMPLEX, COSMETIC AND EXTERNAL PREPARATION FOR SKIN
(FR) AGENT DE BLANCHIMENT, PROMOTEUR DE PRODUCTION D'ACIDE HYALURONIQUE, PROMOTEUR DE PRODUCTION DE COLLAGÈNE, PIÉGEUR D'OXYGÈNE ACTIF INTRACELLULAIRE, ATTÉNUATEUR D'IRRITATION, AGENT D'AMÉLIORATION DES RIDES, COMPLEXE, PRODUIT COSMÉTIQUE ET PRÉPARATION EXTERNE POUR LA PEAU
(JA) 美白剤、ヒアルロン酸産生促進剤、コラーゲン産生促進剤、細胞内活性酸素消去剤、刺激緩和剤、シワ改善剤、複合体、化粧料、及び皮膚外用剤
Abstract
(EN)
The present invention provides new uses of phosphatidylinositol. Further, the present invention provides a composition capable of easily and stably dispersing phosphatidylinositol in water and a technique whereby phosphatidylinositol can be easily and stably dispersed in water. Phosphatidylinositol (PI), in particular, a PI-rich composition produced by a specific method can be used as a whitening agent, a hyaluronic acid production promoter, a collagen production promoter, an intracellular active oxygen scavenger, an irritation mitigator and a wrinkle-ameliorating agent. The problem of the present invention can be solved by: a complex obtained by, from a solution in which component (A1) which is phosphatidylinositol, component (A2) which is lecithin and component (A3) which is a sterol are homogeneously dissolved in an organic solvent, removing the organic solvent and thus simultaneously precipitating components (A1) to (A3); and a cosmetic or an external preparation for skin which contains, as essential components, component (A) which is a composition comprising phosphatidylinositol and lecithin, component (B) which is a polyhydric alcohol and component (C) which is water.
(FR)
La présente invention concerne de nouvelles utilisations du phosphatidylinositol. En outre, la présente invention concerne une composition capable de disperser facilement et de manière stable le phosphatidylinositol dans l'eau et une technique par laquelle le phosphatidylinositol peut être dispersé facilement et de façon stable dans l'eau. Le phosphatidylinositol (PI), en particulier, une composition riche en PI produite par un procédé spécifique peut être utilisé comme agent de blanchiment, promoteur de production d'acide hyaluronique, promoteur de production de collagène, piégeur d'oxygène actif intracellulaire, atténuateur d'irritation et agent d'amélioration des rides. Le problème de la présente invention peut être résolu par : un complexe obtenu par, à partir d'une solution dans laquelle le composant (A1) qui est le phosphatidylinositol, le composant (A2) qui est la lécithine et le composant (A3) qui est un stérol sont dissous de manière homogène dans un solvant organique, élimination du solvant organique et ainsi précipitation simultanée de composants (A1) à (A3) ; et un produit cosmétique ou une préparation externe pour la peau qui contient, en tant que composants essentiels, le composant (A) qui est une composition comprenant du phosphatidylinositol et de la lécithine, le composant (B) qui est un alcool polyhydrique et le composant (C) qui est de l'eau.
(JA)
本発明は、ホスファチジルイノシトールについて新たな用途を提供する。またホスファチジルイノシトールを水に簡便かつ安定に分散させることができる組成物、及び、水に簡便かつ安定に分散させる技術を提供する。 ホスファチジルイノシトール(PI)、特に特定の方法で製造される高濃度PI組成物は、美白剤、ヒアルロン酸産生促進剤、コラーゲン産生促進剤、細胞内活性酸素消去剤、刺激緩和剤、シワ改善剤として利用できる。 成分(A1)ホスファチジルイノシトール、成分(A2)レシチン、及び、成分(A3)ステロール類が有機溶媒中に均一に溶解している溶液から有機溶媒を除去して、成分(A1)~(A3)を同時に析出せしめて得られる複合体、並びに、成分(A)ホスファチジルイノシトール及びレシチンからなる組成物、成分(B)多価アルコール、及び、成分(C)水を必須成分として含有する化粧料又は皮膚外用剤は、本発明の課題を解決するものである。
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