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1. WO2020136696 - METHOD FOR INDUCING MUSCULAR CELLS USING CELLS IN SPOT URINE

Publication Number WO/2020/136696
Publication Date 02.07.2020
International Application No. PCT/JP2018/047447
International Filing Date 25.12.2018
IPC
C12N 5/07 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
A61P 19/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
C12Q 1/02 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
CPC
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
C12Q 1/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
Applicants
  • 国立研究開発法人国立精神・神経医療研究センター NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY [JP]/[JP]
  • 日本新薬株式会社 NIPPON SHINYAKU CO., LTD. [JP]/[JP]
Inventors
  • 滝澤 歩武 TAKIZAWA Hotake
  • 青木 吉嗣 AOKI Yoshitsugu
  • 武田 伸一 TAKEDA Shin'ichi
  • 塩谷 由輝子 ENYA Yukiko
  • 戸根 悠一郎 TONE Yuichiro
Agents
  • 特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES
Priority Data
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR INDUCING MUSCULAR CELLS USING CELLS IN SPOT URINE
(FR) PROCÉDÉ D'INDUCTION DE CELLULES MUSCULAIRES À L'AIDE DE CELLULES DANS LE SPOT URINAIRE
(JA) 随時尿中細胞を用いた筋系細胞の誘導方法
Abstract
(EN)
The present invention provides a non-invasive and simple method for producing myotubes, and establishes an in vitro testing system for an exon-skipping therapeutic drug for muscular dystrophy. Specifically, the present invention pertains to a method that is for producing myotubes from cells in urine, and that comprises an introduction step for introducing the MYOD1 gene into cells in urine, and an exposure step for exposing the cells in urine to at least one epigenetic control compound.
(FR)
La présente invention concerne un procédé non invasif et simple de production de myotubes, et établit un système de test in vitro pour un médicament thérapeutique à saut d'exon pour dystrophie musculaire. Plus particulièrement, la présente invention concerne un procédé permettant de produire des myotubes à partir de cellules dans l'urine, et comprenant une étape d'introduction pour introduire le gène MYOD1 dans des cellules dans l'urine, et une étape d'exposition pour exposer les cellules dans l'urine à au moins un composé de contrôle épigénétique.
(JA)
本発明は、無侵襲かつ簡便な筋管の作製方法を提供し、筋ジストロフィーのエクソン・スキップ治療薬のin vitro検定系を確立する。具体的には、本発明は、尿中細胞にMYOD1遺伝子を導入する導入ステップと、前記尿中細胞を少なくとも1種のエピジェネティクス制御化合物に曝露する曝露ステップと、を含む、尿中細胞から筋管を作製する方法に関する。
Related patent documents
JP2020561982This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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