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1. WO2020136693 - SUBSTITUTED QUINOLONE COMPOUNDS, THEIR USE IN THE TREATMENT OF CANCER, AND A METHOD FOR PREPARATION

Publication Number WO/2020/136693
Publication Date 02.07.2020
International Application No. PCT/JO2019/050005
International Filing Date 07.01.2019
IPC
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 471/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
06Peri-condensed systems
CPC
C07D 215/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
C07D 319/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
319Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
041,3-Dioxanes; Hydrogenated 1,3-dioxanes
06not condensed with other rings
Applicants
  • UNIVERSITY OF PETRA [JO]/[JO]
Inventors
  • AL-SHEIKH, Ahmad
  • ARAFAT, Tawfiq
  • ABUQATOUSEH, Luay
  • MALLAH, Eyad
Agents
  • THE INTELLECTUAL PROPERTY COMMERCIALIZATION OFFICE/ ROYAL SCIENTIFIC SOCIETY
Priority Data
JO/P/2018/013124.12.2018JO
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED QUINOLONE COMPOUNDS, THEIR USE IN THE TREATMENT OF CANCER, AND A METHOD FOR PREPARATION
(FR) COMPOSÉS DE QUINOLONE SUBSTITUÉS, LEUR UTILISATION DANS LE TRAITEMENT DU CANCER ET PROCÉDÉ DE PRÉPARATION
Abstract
(EN)
The present disclosure provides a compound of Formula (I) or any pharmaceutically acceptable salt thereof for use in treating cancer in a subject, a method for preparing the same, and a pharmaceutical composition thereof: Formula (I) wherein R1 comprises H; C1–C3 alkyl; or C3–C6cycloalkyl; R2 comprises H; or C1–C2 alkyl; C1–C2 –O alkyl; R3 comprises H; C1–C2 alkyl, aryl or substituted aryl, H2C-aryl or substituted H2C-aryl; and R4 comprises H; C1–C3 alkyl; O-alkyl or O-aryl.
(FR)
La présente invention concerne un composé de formule (I) ou un quelconque sel pharmaceutiquement acceptable de celui-ci, destiné à être utilisé dans le traitement du cancer chez un sujet, un procédé pour sa préparation et une composition pharmaceutique correspondante : Formule (I) dans laquelle R1 comprend H ; alkyle en C1–C3 ; ou cycloalkyle en C3–C6 ; R2 comprend H ; ou alkyle en C1–C2 ; alkyle en C1–C2 –O ; R3 comprend H ; alkyle en C1–C2, aryle ou aryle substitué, aryle en H2C ou aryle en H2C substitué ; et R4 comprend H ; alkyle en C1–C3 ; O-alkyle ou O-aryle.
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