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1. WO2020136671 - IMPROVED PROCESS FOR THE PREPARATION OF LAPATINIB BASE AND IT'S ANHYDROUS DITOSYLATE SALT

Publication Number WO/2020/136671
Publication Date 02.07.2020
International Application No. PCT/IN2019/050930
International Filing Date 17.12.2019
IPC
C07D 405/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
CPC
C07D 405/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
Applicants
  • NATCO PHARMA LIMITED [IN]/[IN]
Inventors
  • BUDIDETI, Shankar Reddy
  • ABAYEE KALIYAPERUMAL, Srinivasan
  • KONDURI, Srinivasa Krishna Murthy
  • KASUGANTI, Jayakrishna
  • SAMATHAM, Nagalingam
  • CHAPALA, Vijaya Lakshmi
  • MUDDASANI, Pulla Reddy
  • NANNAPANENI, Venkaiah Chowdary
Priority Data
20184104925227.12.2018IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED PROCESS FOR THE PREPARATION OF LAPATINIB BASE AND IT'S ANHYDROUS DITOSYLATE SALT
(FR) PROCÉDÉ PERFECTIONNÉ POUR LA PRÉPARATION D'UNE BASE DE LAPATINIB ET DE SON SEL DE DITOSYLATE ANHYDRE
Abstract
(EN)
The present invention relates to an improved, high yielding and industrially viable process for the preparation of high pure Lapatinib of formula (1). The present invention involves simple crystallization techniques avoiding column chromatographic techniques and the process conditions can be easily adopted for scale-up studies.
(FR)
La présente invention concerne un un procédé perfectionné, à haut rendement et viable sur le plan industriel pour la préparation de lapatinib de haute pureté de formule (1). La présente invention implique des techniques de cristallisation simples évitant les techniques de chromatographie sur colonne et les conditions de traitement peuvent être facilement adoptées pour des études de mise à l'échelle.
Latest bibliographic data on file with the International Bureau