Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020136665 - PREPARATION OF COVALENTLY HEPARIN-POLYMER CONJUGATE AND; USE THEREOF

Publication Number WO/2020/136665
Publication Date 02.07.2020
International Application No. PCT/IN2019/050331
International Filing Date 24.04.2019
IPC
A61L 33/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
A61L 33/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
06Use of macromolecular materials
08Polysaccharides
10Heparin, heparinoid or derivatives thereof
A61L 31/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
14Materials characterised by their function or physical properties
16Biologically active materials, e.g. therapeutic substances
A61L 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
04Macromolecular materials
CPC
A61L 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
04Macromolecular materials
A61L 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
14Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
16Biologically active materials, e.g. therapeutic substances
A61L 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
Applicants
  • PATEL, Himanshu [IN]/[IN]
Inventors
  • PATEL, Himanshu
Priority Data
20182104890324.12.2018IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PREPARATION OF COVALENTLY HEPARIN-POLYMER CONJUGATE AND; USE THEREOF
(FR) PRÉPARATION D’UN CONJUGUÉ COVALENT D’HÉPARINE-POLYMÈRE ET SON UTILISATION
Abstract
(EN)
Present invention discloses preparation of covalent conjugate Heparin – polymer using carboxyl group of Heparin sodium and terminal hydroxyl and/or group of amino group of polymer. This attachment is conducted for increasing the compatibility of polymer without affecting the properties of polymer and Heparin. For conjugation, the chemical reaction is conducted using catalyst and coupling reagent in presence of solvent. The ACT and TBA method is accomplished to determine total Heparin content of final product. For bio-compatibility, Protein Adsorption, APTT, PT, Platelet Adhesion and Leukocyte Adhesion of conjugate material are investigated. Degradation study of Heparin -PLLA is also carried. Covalently attached Heparin – Polymer is further used in various pharmaceutical industries.
(FR)
La présente invention concerne la préparation d’un conjugué covalent d’héparine-polymère faisant intervenir un groupe carboxyle d’héparine sodique et un groupe hydroxyle terminal et/ou un groupe amino du polymère. Cette fixation est effectuée de manière à accroître la compatibilité du polymère sans affecter les propriétés du polymère ni de l’héparine. Pour la conjugaison, la réaction chimique est conduite à l'aide d'un catalyseur et d'un réactif de couplage en présence de solvant. Le procédé ACT et TBA est accompli pour déterminer la teneur totale en héparine du produit final. Pour la bio-compatibilité, la présente invention étudie l’adsorption de protéine, l’APTT, PT, l’adhésion des plaquettes et l’adhésion des leucocytes du matériau conjugué. L’invention effectue également l’étude de dégradation de l’héparine-PLLA. L’héparine-polymère lié de manière covalente est en outre utilisé dans diverses industries pharmaceutiques.
Latest bibliographic data on file with the International Bureau