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1. WO2020136550 - STABLE MICROSPHERES, METHOD OF FABRICATION AND USE THEREOF

Publication Number WO/2020/136550
Publication Date 02.07.2020
International Application No. PCT/IB2019/061279
International Filing Date 23.12.2019
IPC
A61K 9/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
A61K 41/00 2020.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
CPC
A61K 41/0028
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0028Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
A61K 9/5031
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5005Wall or coating material
5021Organic macromolecular compounds
5031obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
A61K 9/5089
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5089Processes
Applicants
  • B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY [IL]/[IL]
Inventors
  • TSIRKIN, Shani
  • KOST, Joseph
  • TRAITEL, Tamar
  • GOLDBART, Riki
Agents
  • SHIMONI, Gila
  • RICHTER, Allen
Priority Data
62/784,47723.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STABLE MICROSPHERES, METHOD OF FABRICATION AND USE THEREOF
(FR) MICROSPHÈRES STABLES, LEURS PROCÉDÉS DE FABRICATION ET LEUR UTILISATION
Abstract
(EN)
Stable and durable polymeric microbubbles of a 1-10 μm size range are disclosed. The microbubbles are synthesized from the co-polymer poly lactic-co-glycolic acid (PLGA), which provides a plurality of PLGA microbubbles presenting diverse cavitation activities. The PLGA microbubbles are particularly suitable for cavitation enhancement purposes and are applicable in various clinical procedures such as ablation or enhancement of uptake of chemical or biological therapy in cells and tissue.
(FR)
L'invention concerne des microbulles polymères stables et durables d'une gamme de tailles de 1 à 10 µm. Les microbulles sont synthétisées à partir de l'acide polylactique-co-glycolique (PLGA) co-polymère, qui fournit une pluralité de microbulles de PLGA présentant diverses activités de cavitation. Les microbulles de PLGA sont particulièrement appropriées à des fins d'amélioration de la cavitation et sont applicables dans diverses procédures cliniques telles que l'ablation ou l'amélioration de l'absorption de thérapie chimique ou biologique dans des cellules et des tissus.
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