Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Tuesday 27.07.2021 at 12:00 PM CEST
Settings

Settings

Goto Application

1. WO2020136361 - FLUIDIC SYSTEM FOR PRODUCING EXTRACELLULAR VESICLES COMPRISING A THERAPEUTIC OR IMAGING AGENT AND ASSOCIATED METHOD

Publication Number WO/2020/136361
Publication Date 02.07.2020
International Application No. PCT/FR2019/053308
International Filing Date 27.12.2019
IPC
C12M 1/06 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
04with gas introduction means
06with agitator, e.g. impeller
C12M 1/34 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12M 1/42 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
42Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
C12M 1/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
CPC
C12M 27/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
27Means for mixing, agitating or circulating fluids in the vessel
02Stirrer or mobile mixing elements
C12M 29/18
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
29Means for introduction, extraction or recirculation of materials, e.g. pumps
18External loop; Means for reintroduction of fermented biomass or liquid percolate
C12M 35/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
35Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
04Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
C12M 41/42
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
41Means for regulation, monitoring, measurement or control, e.g. flow regulation
42of agitation speed
C12M 47/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
47Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
10Separation or concentration of fermentation products
Applicants
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR]/[FR]
  • UNIVERSITE DE LORRAINE [FR]/[FR]
  • UNIVERSITE DE PARIS [FR]/[FR]
Inventors
  • MARANGON, Iris
  • MILLARD, Marie
  • BOLOTINE, Lina
  • SILVA, Amanda
  • GRANGIER, Alice
  • GAZEAU, Florence
  • WILHELM, Claire
  • PIFFOUX, Max
Agents
  • GRANDCLAUDE, Virgile
Priority Data
FR187431328.12.2018FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) FLUIDIC SYSTEM FOR PRODUCING EXTRACELLULAR VESICLES COMPRISING A THERAPEUTIC OR IMAGING AGENT AND ASSOCIATED METHOD
(FR) SYSTEME FLUIDIQUE DE PRODUCTION DE VESICULES EXTRACELLULAIRES COMPRENANT UN AGENT THERAPEUTIQUE OU D'IMAGERIE ET PROCEDE ASSOCIE
Abstract
(EN)
The invention relates to a fluidic system for loading a therapeutic or imaging agent into the lumen of extracellular vesicles (EV) from producer cells, comprising at least one container, a liquid medium contained in the container, producer cells, a liquid medium stirrer and means for controlling the speed of the stirrer suitable for the growth of the producer cells, characterized in that it also comprises means for controlling the speed of the stirrer and the stirrer, of which the shape and dimensions of the container are suitable for generating a turbulent flow of the liquid medium in the container for exerting shear stresses on the producer cells in order to carry out the loading of a therapeutic or imaging agent into the lumen of the extracellular vesicles (EV) produced simultaneously by the fluidic system.
(FR)
L'invention concerne un système fluidique de chargement d'un agent thérapeutique ou d'imagerie dans la lumière de vésicules extracellulaires (EV) à partir de cellules productrices, comprenant au moins un récipient, un milieu liquide contenu par le récipient, des cellules productrices, un agitateur de milieu liquide et des moyens de commande de la vitesse de l'agitateur adaptés pour la croissance des cellules productrices, caractérisé en ce qu'il comprend également des moyens de commande de la vitesse de l'agitateur et l'agitateur dont la forme et les dimensions du récipient sont adaptés à la génération d'un écoulement turbulent du milieu liquide dans le récipient pour exercer des contraintes de cisaillement sur les cellules productrices afin de réaliser le chargement d'un agent thérapeutique ou d'imagerie dans la lumière des vésicules extracellulaires (EV) produites simultanément par le système fluidique.
Latest bibliographic data on file with the International Bureau