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1. WO2020136218 - BTN3A BINDING PROTEINS AND USES THEREOF

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Publication Number WO/2020/136218
Publication Date 02.07.2020
International Application No. PCT/EP2019/087040
International Filing Date 26.12.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/2818
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2818against CD28 or CD152
C07K 16/2827
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2827against B7 molecules, e.g. CD80, CD86
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/54
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
54F(ab')2
C07K 2317/55
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
55Fab or Fab'
Applicants
  • IMCHECK THERAPEUTICS SAS [FR]/[FR]
  • INSTITUT JEAN PAOLI & IRENE CALMETTES [FR]/[FR]
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - [FR]/[FR]
  • INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]/[FR]
  • UNIVERSITÉ D'AIX-MARSEILLE [FR]/[FR]
Inventors
  • TRUNEH, Alemseged
  • PASERO, Christine
  • HOET, René
  • COLAZET, Magali
  • OLIVE, Daniel
Agents
  • PLASSERAUD IP
Priority Data
18306845.126.12.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BTN3A BINDING PROTEINS AND USES THEREOF
(FR) PROTÉINES DE LIAISON BTN3A ET LEURS UTILISATIONS
Abstract
(EN)
It is disclosed anti-BTN3A activating antibody fragments that specifically bind to BTN3A and activate the cytolytic function of Vγ9/Vδ2 T cells. The disclosure more specifically relates to specific anti-BTN3A binding proteins comprising such activating antibody fragments and their use in the manufacturing of novel drugs for use in treating cancer disorders, in particular cancers susceptible to be treated with activated γδ T cells.
(FR)
L'invention concerne des fragments d'anticorps d'activation anti-BTN3A qui se lient spécifiquement à BTN3A et activent la fonction cytolytique de lymphocytes T Vγ9/Vδ2. L'invention concerne plus particulièrement des protéines de liaison anti-BTN3A spécifiques comprenant de tels fragments d'anticorps d'activation et leur utilisation dans la fabrication de nouveaux médicaments destinés à être utilisés dans le traitement de troubles cancéreux, en particulier de cancers susceptibles d'être traités par des lymphocytes T γδ activés.
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