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1. WO2020136192 - METHOD FOR MEASURING TELOMERE ASSOCIATED VARIABLES AND USES THEREOF FOR THE DIAGNOSIS AND/OR PROGNOSIS OF TELOMERIC-ASSOCIATED DISEASES

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Publication Number WO/2020/136192
Publication Date 02.07.2020
International Application No. PCT/EP2019/087005
International Filing Date 24.12.2019
Chapter 2 Demand Filed 23.10.2020
IPC
C12Q 1/6841 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6841In situ hybridisation
G16B 5/00 2019.1
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
5ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
CPC
C12Q 1/6841
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
6841In situ hybridisation
C12Q 1/6851
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6844Nucleic acid amplification reactions
6851Quantitative amplification
C12Q 1/6876
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
C12Q 2600/106
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
C12Q 2600/166
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
166Oligonucleotides used as internal standards, controls or normalisation probes
Applicants
  • LIFE LENGTH, S.L. [ES]/[ES]
Inventors
  • NAJARRO PARRA, María Pilar
  • FERNÁNDEZ CANIVELL, Luis
  • ESTEBAN LA FUENTE, Laura
  • DE PEDRO MONTEJO, Nuria
  • DIEZ ZAERA, María
  • GARCIA MARTÍNEZ, Jorge
Agents
  • PONS ARIÑO, Angel
Priority Data
18382992.826.12.2018EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR MEASURING TELOMERE ASSOCIATED VARIABLES AND USES THEREOF FOR THE DIAGNOSIS AND/OR PROGNOSIS OF TELOMERIC-ASSOCIATED DISEASES
(FR) PROCÉDÉ DE MESURE DE VARIABLES ASSOCIÉES AU TÉLOMÈRES ET LEURS UTILISATIONS POUR LE DIAGNOSTIC ET/OU LE PRONOSTIC DE MALADIES ASSOCIÉES AU TÉLOMÈRES
Abstract
(EN) The invention provided methods in vitro for diagnosis and/or prognosis of a clinical outcome in a subject with a telomere-associated disease comprising determining specific telomere associated variables (TAVs) of a test sample cell from the subject, wherein the value of the TAVs obtained for the test sample compared to a control sample is indicative of the telomerase-associated disease and/or the clinical outcome of the subject.
(FR) L'invention concerne des procédés in vitro pour le diagnostic et/ou le pronostic d'un résultat clinique chez un sujet atteint d'une maladie associée aux télomères, comprenant la détermination de variables associées à des télomères spécifiques (TAV) d'une cellule d'échantillon à analyser prélevée chez le sujet, la valeur des TAV obtenues pour l'échantillon à analyser par comparaison avec un échantillon témoin indiquant la maladie associée à la télomérase et/ou le résultat clinique du sujet.
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