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1. WO2020136153 - USE OF SIDEROMYCINS TO LIMIT CROSS-REACTIVITY AND IMPROVE BACTERIAL IDENTIFICATION IN ANTIBIOTIC SUSCEPTIBILITY ASSAYS

Publication Number WO/2020/136153
Publication Date 02.07.2020
International Application No. PCT/EP2019/086886
International Filing Date 22.12.2019
IPC
C12Q 1/689 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
C12Q 1/6897 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6897involving reporter genes operably linked to promoters
CPC
C12Q 1/689
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
C12Q 1/6897
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6897involving reporter genes operably linked to promoters
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • ROCHE DIAGNOSTICS GMBH [DE]/[DE] (DE)
  • ROCHE MOLECULAR SYSTEMS, INC. [US]/[US] (US)
Inventors
  • CADY, Kyle C.
  • CHAN, Ryan
Agents
  • HÖVELMANN, Sascha
Priority Data
62/786,43129.12.2018US
62/858,14606.06.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF SIDEROMYCINS TO LIMIT CROSS-REACTIVITY AND IMPROVE BACTERIAL IDENTIFICATION IN ANTIBIOTIC SUSCEPTIBILITY ASSAYS
(FR) UTILISATION DE SIDÉROMYCINES POUR LIMITER LA RÉACTIVITÉ CROISÉE ET AMÉLIORER L'IDENTIFICATION BACTÉRIENNE LORS DES DOSAGES DE SENSIBILITÉ AUX ANTIBIOTIQUES
Abstract
(EN)
The present invention relates to the use of sideromycins as additives in non-replicative transduction particles based systems to either limit cross-reactivity of unwanted organisms or to identify the organism being run on an antibiotic susceptibility assay (AST assay). Addition of the sideromycins removes or reduces light production from bacteria that are sensitive to them, allowing for prevention of cross-reactivity in AST assays and/or family, genus, and potentially species level bacteria strain identification when performing AST testing.
(FR)
La présente invention concerne l'utilisation de sidéromycines comme additifs dans des systèmes à base de particules de transduction non réplicatives pour limiter la réactivité croisée d'organismes indésirables ou pour identifier l'organisme étant impliqué lors d'un dosage de sensibilité aux antibiotiques (dosage AST). L'addition des sidéromycines élimine ou réduit la production de lumière à partir de bactéries étant sensibles à ces dernières, permettant de prévenir la réactivité croisée lors des dosages AST et/ou identifier la souche bactérienne au niveau de la famille, du genre et potentiellement de l'espèce lors de la réalisation d'un dosage AST.
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