WO2020135920 KIT FOR INHALED CHEMOTHERAPY, AND TREATMENT OF LUNG CANCER WITH SAID KIT

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Publication Number WO/2020/135920

Publication Date 02.07.2020

International Application No. PCT/EP2018/097140

International Filing Date 28.12.2018

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Applicants

UNIVERSITÉ LIBRE DE BRUXELLES [BE]/[BE]

Inventors

AMIGHI, Karim
WAUTHOZ, Nathalie
ROSIÈRE, Rémi

Agents

CALYSTA NV

Priority Data

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) KIT FOR INHALED CHEMOTHERAPY, AND TREATMENT OF LUNG CANCER WITH SAID KIT

(FR) KIT POUR CHIMIOTHÉRAPIE INHALÉE ET TRAITEMENT DU CANCER DU POUMON À L'AIDE DUDIT KIT

Abstract

(EN) Kit for an inhaled chemotherapy comprising a series of single hermetically packaged therapeutic doses of a dry powder for inhalation containing at least one anti-neoplastic agent chosen in the group consisting of platinum drugs with a lipid matrix and a PEGylated excipient and a series of disposable dry powder inhaler devices, its use and method of treatment of cancer lungs with said kit.

(FR) L'invention concerne un kit pour une chimiothérapie inhalée comprenant une série de doses thérapeutiques individuelles hermétiquement emballées d'une poudre sèche pour inhalation contenant au moins un agent antinéoplasique choisi dans le groupe constitué par des médicaments à base de platine avec une matrice lipidique et un excipient PEGylé et une série de dispositifs inhalateurs de poudre sèche jetables, son utilisation et une méthode de traitement des poumons cancéreux à l'aide dudit kit.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33	Medicinal preparations containing inorganic active ingredients
24	Heavy metals; Compounds thereof

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33	Medicinal preparations containing inorganic active ingredients
24	Heavy metals; Compounds thereof
243	Platinum; Compounds thereof

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
14	Particulate form, e.g. powders

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1. WO2020135920 - KIT FOR INHALED CHEMOTHERAPY, AND TREATMENT OF LUNG CANCER WITH SAID KIT

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
M	DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
15	Inhalators
0028	using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
003	using capsules, e.g. to be perforated or broken-up

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
22	Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24	containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
14	Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
141	Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
148	with compounds of unknown constitution, e.g. material from plants or animals

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
22	Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones