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1. WO2020135555 - BIVALENT BISPECIFIC ANTIBODY AND PREPARTION METHOD THEREOF, CODING GENE, HOST CELL AND COMPOSITION

Publication Number WO/2020/135555
Publication Date 02.07.2020
International Application No. PCT/CN2019/128582
International Filing Date 26.12.2019
IPC
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C07K 16/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/2803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
C07K 16/2827
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2827against B7 molecules, e.g. CD80, CD86
C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
Applicants
  • 长春金赛药业有限责任公司 CHANGCHUN GENESCIENCE PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 冯晓 FENG, Xiao
  • 金磊 JIN, Lei
  • 王涛 WANG, Tao
  • 郭洪瑞 GUO, Hongrui
  • 刘爽 LIU, Shuang
  • 陈宇珩 CHEN, Yuheng
  • 韩宁 HAN, Ning
  • 梁阳秋 LIANG, Yangqiu
Agents
  • 北京集佳知识产权代理有限公司 UNITALEN ATTORNEYS AT LAW
Priority Data
201811622069.228.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BIVALENT BISPECIFIC ANTIBODY AND PREPARTION METHOD THEREOF, CODING GENE, HOST CELL AND COMPOSITION
(FR) ANTICORPS BISPÉCIFIQUE BIVALENT ET SON PROCÉDÉ DE PRÉPARATION, GÈNE CODANT, CELLULE HÔTE ET COMPOSITION
(ZH) 二价双特异性抗体及其制备方法、编码基因、宿主细胞、组合物
Abstract
(EN)
Provided are a bivalent bispecific antibody and a preparation method thereof, a coding gene, a host cell and a composition. The bivalent bispecific antibody comprises: a) a single-chain variable fragment scFv, a flexible peptide, a heavy chain IgG1 constant region CH1 and a hinge region partial sequence of the antibody that specifically binds to a first antigen, and b) a single-chain variable fragment scFv, and a light chain constant region CL, that is, scFv1-CL or CL-scFv1, of the antibody that specifically binds to a second antigen; or comprises: c) a light chain and a heavy chain of the antibody that specifically binds to the first antigen, and d) a light chain and a heavy chain of the antibody that specifically binds to the second antigen.
(FR)
L'invention concerne un anticorps bispécifique bivalent et son procédé de préparation, un gène codant, une cellule hôte et une composition. L'anticorps bispécifique bivalent comprend : a) un fragment variable scFv à chaîne unique, un peptide flexible, une région constante d'IgG1 à chaîne lourde CH1 et une séquence partielle d'une région charnière de l'anticorps se liant de manière spécifique à un premier antigène, et b) un fragment variable scFv à chaîne unique, et une région constante de chaîne légère CL, qui est, scFv1-CL ou CL-scFv1, de l'anticorps se liant de manière spécifique à un second antigène; ou comprend : c) une chaîne légère et une chaîne lourde de l'anticorps se liant de manière spécifique au premier antigène, et d) une chaîne légère et une chaîne lourde de l'anticorps se liant de manière spécifique au second antigène.
(ZH)
提供二价双特异性抗体及其制备方法、编码基因、宿主细胞、组合物。该二价双特异性抗体包括:a)特异性结合第一抗原的抗体的单链可变片段scFv、柔性肽、重链IgG1恒定区CH1以及铰链区部分序列,和b)特异性结合第二抗原的抗体的单链可变片段scFv和轻链恒定区CL,即scFv1-CL或CL-scFv1;或者包括:c)特异性结合第一抗原的抗体的轻链和重链;和d)特异性结合第二抗原的抗体的轻链和重链。
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