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1. WO2020135507 - POLYSUBSTITUTED ANILINOPYRIMIDINE DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF

Publication Number WO/2020/135507
Publication Date 02.07.2020
International Application No. PCT/CN2019/128325
International Filing Date 25.12.2019
IPC
C07D 403/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 405/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07D 403/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 405/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
Applicants
  • 杭州百新生物医药科技有限公司 HANGZHOU BIO-CREATIVITY PHARMA-TECH CO. ,LTD. [CN]/[CN]
Inventors
  • 楼金芳 LOU, Jinfang
  • 盛荣 SHENG, Rong
  • 张冯敏 ZHANG, Fengmin
  • 冯恩光 FENG, Enguang
Agents
  • 杭州求是专利事务所有限公司 HANGZHOU QIUSHI PATENT OFFICE CO.,LTD.
Priority Data
201811597532.226.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) POLYSUBSTITUTED ANILINOPYRIMIDINE DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF
(FR) DÉRIVÉ D'ANILINOPYRIMIDINE POLYSUBSTITUÉ, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION
(ZH) 一种多取代苯氨基嘧啶衍生物及其制备方法和用途
Abstract
(EN)
Disclosed in the present invention are a polysubstituted anilinopyrimidine derivative having a structure of general formula I, and a preparation method and application thereof, the derivative and a pharmaceutically acceptable salt or solvent compound thereof being a kinase CDK4, CDK6 and/or CDK 9 inhibitor, capable of more broadly being used in cancer treatment, and having great clinical application value.
(FR)
La présente invention concerne un dérivé d'anilinopyrimidine polysubstitué ayant une structure de formule générale I, son procédé de préparation et son application, le dérivé et un sel pharmaceutiquement acceptable ou un composé de solvant de celui-ci étant un inhibiteur de kinase CDK4, CDK6 et/ou CDK 9, capable d'être utilisé plus largement dans le traitement du cancer, et ayant une grande valeur d'application clinique.
(ZH)
本发明公开了一种具有通式Ⅰ结构的多取代苯氨基嘧啶衍生物及其制备方法和用途,该类衍生物及其药学上可接受的盐或溶剂化合物是激酶CDK4、CDK6和/或CDK9抑制剂,可更广泛地用于癌症的治疗,具有巨大的临床应用价值。
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