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1. WO2020135439 - DEUTERATED DIHYDROPYRIMIDINE COMPOUND AND USE THEREOF AS DRUG

Publication Number WO/2020/135439
Publication Date 02.07.2020
International Application No. PCT/CN2019/128015
International Filing Date 24.12.2019
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/4985 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
C07D 498/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 513/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
CPC
A61K 31/4985
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 498/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 513/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 广东东阳光药业有限公司 SUNSHINE LAKE PHARMA CO., LTD. [CN]/[CN]
Inventors
  • 任青云 REN, Qingyun
  • 刘辛昌 LIU, Xinchang
  • 张英俊 ZHANG, Yingjun
  • S•戈尔德曼 SIEGFRIED, Goldmann
  • 王猛 WANG, Meng
  • 丘荣茂 QIU, Rongmao
  • 颜光华 YAN, Guanghua
  • 雷斗兴 LEI, Douxing
  • 李凤 LI, Feng
  • 邹致富 ZOU, Zhifu
Priority Data
201811592167.625.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) DEUTERATED DIHYDROPYRIMIDINE COMPOUND AND USE THEREOF AS DRUG
(FR) COMPOSÉ DIHYDROPYRIMIDINE DEUTÉRÉ ET SON UTILISATION EN TANT QUE MÉDICAMENT
(ZH) 氘代二氢嘧啶类化合物及其在药物中的应用
Abstract
(EN)
A deuterated dihydropyrimidine compound and use thereof as a drug, especially as a drug for treating and preventing hepatitis B. In particular, the present invention relates to a compound represented by general formula (I) or (Ia) or a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variate is as defined in the description. The present invention also relates to use of the compound represented by general formula (I) or (Ia) or a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, or a pharmaceutically acceptable salt thereof as a drug, in particular as a drug for treating and preventing hepatitis B. (I), (IA)
(FR)
La présente invention concerne un composé dihydropyrimidine deutéré et une utilisation correspondante en tant que médicament, en particulier en tant que médicament pour le traitement et/ou la prévention de l'hépatite B. Plus particulièrement, l'invention concerne un composé représenté par la formule générale (I) ou (Ia) ou un stéréoisomère, un tautomère, un oxynitrure, un solvate, un métabolite, un sel pharmaceutiquement acceptable ou un promédicament de celui-ci, chaque variant étant tel que défini dans la description. La présente invention concerne également l'utilisation du composé représenté par la formule générale (I) ou (Ia) ou un stéréoisomère, un tautomère, un oxynitrure, un solvate, un métabolite, ou un sel pharmaceutiquement acceptable de celui-ci en tant que médicament, en particulier en tant que médicament pour le traitement et la prévention de l'hépatite B. (I), (IA)
(ZH)
一种氘代二氢嘧啶类化合物及其作为药物的用途,尤其是作为治疗和预防乙型肝炎的药物的应用。具体地说,涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或它的前药,其中各变量如说明书所定义。还涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐作为药物的用途,尤其是作为治疗和预防乙型肝炎的药物的用途。(I),(IA)
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