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1. WO2020135058 - NEW CRYSTAL FORM OF ROXADUSTAT AND PREPARATION METHOD THEREOF

Publication Number WO/2020/135058
Publication Date 02.07.2020
International Application No. PCT/CN2019/124634
International Filing Date 11.12.2019
IPC
C07D 217/26 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
A61P 13/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 7/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
06Antianaemics
A61K 31/472 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
CPC
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 7/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
06Antianaemics
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07D 217/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Applicants
  • 安礼特(上海)医药科技有限公司 ARIZEST (SHANGHAI) PHARMATECH CO., LTD. [CN]/[CN]
  • 江苏创诺制药有限公司 JIANGSU ACEBRIGHT PHARMACEUTICALS CO., LTD. [CN]/[CN]
  • 上海创诺医药集团有限公司 SHANGHAI ACEBRIGHT PHARMACEUTICALS GROUP CO., LTD. [CN]/[CN]
Inventors
  • 李庆秋 LI, Qingqiu
  • 申淑匣 SHEN, Shuxia
  • 修平 XIU, Ping
  • 张良 ZHANG, Liang
Agents
  • 上海一平知识产权代理有限公司 XU & PARTNERS, LLC.
Priority Data
201811639233.029.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) NEW CRYSTAL FORM OF ROXADUSTAT AND PREPARATION METHOD THEREOF
(FR) NOUVELLE FORME CRISTALLINE DE ROXADUSTAT ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
(ZH) 罗沙司它的新晶型及其制备方法
Abstract
(EN)
Provided is a new crystal form of roxadustat and a preparation method thereof. The crystal form ARZ-A provided by the present invention has better stability and better solubility than the original crystal form. The preparation process of the crystal form provided by the invention is simple and easy, and the toxicity of the solvent used is small, the stability of the crystal form is good, and thus the preparation process is more suitable for scaled-up production. (I)
(FR)
La présente invention concerne une nouvelle forme cristalline de roxadustat et un procédé de préparation associé. La forme cristalline ARZ-A fournie par la présente invention a une meilleure stabilité et une meilleure solubilité que la forme cristalline d'origine. Le procédé de préparation de la forme cristalline fourni par l'invention est simple et facile, et la toxicité du solvant utilisé est faible, la stabilité de la forme cristalline est bonne, et par conséquent le procédé de préparation est plus approprié pour une mise à l'échelle de production. (I)
(ZH)
本发明提供了罗沙司它的新晶型及其制备方法。本发明提供的晶型ARZ-A具有比原研晶型更好的稳定性及更好的溶解度。本发明提供的晶型的制备工艺简便易行,且使用的溶剂的毒性小,晶型的稳定性好,更适合工艺放大生产。(I)
Also published as
Latest bibliographic data on file with the International Bureau