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1. WO2020134950 - GENE MUTATION/FUSION COMBINATION AND KIT FOR IDENTIFICATION OF BENIGN AND MALIGNANT PULMONARY NODULES

Publication Number WO/2020/134950
Publication Date 02.07.2020
International Application No. PCT/CN2019/123432
International Filing Date 05.12.2019
IPC
C12Q 1/6886 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
CPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
Applicants
  • 江苏为真生物医药技术股份有限公司 JIANGSU MICRODIAG BIOMEDICINE TECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 王弢 WANG, Tao
  • 孙爱娟 SUN, Aijuan
  • 乔岩 QIAO, Yan
  • 任小芸 REN, Xiaoyun
  • 徐荣荣 XU, Rongrong
  • 孙玉龙 SUN, Yulong
Agents
  • 北京国昊天诚知识产权代理有限公司 CO-HORIZON INTELLECTUAL PROPERTY INC.
Priority Data
201811630825.629.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) GENE MUTATION/FUSION COMBINATION AND KIT FOR IDENTIFICATION OF BENIGN AND MALIGNANT PULMONARY NODULES
(FR) COMBINAISON DE MUTATION/FUSION DE GÈNES ET KIT POUR L'IDENTIFICATION DE NODULES PULMONAIRES BÉNINS ET MALINS
(ZH) 用于肺结节良恶性鉴别的基因突变/融合组合及试剂盒
Abstract
(EN)
Provided is a gene mutation/fusion combination using plasma as sample and using PCR technology to identify benign and malignant pulmonary nodules. The specific combination is: EGFR/KRAS or EGFR/KRAS/ALK/ROS1 or EGFR/KRAS/BRAF/ALK/ROS1 or EGFR/KRAS/BRAF/ALK/ROS1/STK11/NRAS/TP53/PIK3CA. Also provided is a relevant kit, and a layout of a detection system when the kit is used.
(FR)
L'invention concerne une combinaison de mutation/fusion de gènes utilisant un plasma en tant qu'échantillon et utilisant une technique de PCR pour identifier des nodules pulmonaires bénins et malins. La combinaison spécifique es la suivante: EGFR/KRAS ou EGFR/KRAS/ALK/ROS1 ou EGFR/KRAS/BRAF/ALK/ROS1 ou EGFR/KRAS/BRAF/ALK/ROS1/STK11/NRAS/TP53/PIK3 CA. L'invention concerne également un kit pertinent et une disposition d'un système de détection lorsque le kit est utilisé.
(ZH)
一种以血浆为样品,利用PCR技术鉴别肺结节良恶性的基因突变/融合组合,具体组合为:EGFR/KRAS或EGFR/KRAS/ALK/ROS1或EGFR/KRAS/BRAF/ALK/ROS1或EGFR/KRAS/BRAF/ALK/ROS1/STK11/NRAS/TP53/PIK3CA。以及相关的试剂盒、试剂盒使用时检测体系的布局方式。
Also published as
Latest bibliographic data on file with the International Bureau