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1. WO2020134542 - DRUG ELUTING DEVICE AND MANUFACTURING METHOD THEREOF

Publication Number WO/2020/134542
Publication Date 02.07.2020
International Application No. PCT/CN2019/114702
International Filing Date 31.10.2019
IPC
A61F 2/82 2013.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
CPC
A61F 2/82
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2240/001
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2240Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
001Designing or manufacturing processes
Applicants
  • 元心科技(深圳)有限公司 BIOTYX MEDICAL (SHENZHEN) CO., LTD [CN]/[CN]
Inventors
  • 林文娇 LIN, Wenjiao
  • 胡军 HU, Jun
Agents
  • 北京辰权知识产权代理有限公司 BEIJING CHEN QUAN INTELLECTUAL PROPERTY LAW FIRM
Priority Data
201811593382.825.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) DRUG ELUTING DEVICE AND MANUFACTURING METHOD THEREOF
(FR) DISPOSITIF D'ÉLUTION DE MÉDICAMENT ET SON PROCÉDÉ DE FABRICATION
(ZH) 一种药物洗脱器械及其制造方法
Abstract
(EN)
A drug eluting device and a manufacturing method thereof, the drug eluting device comprising a base (1) and a drug-carrying layer (3); the base (1) having an outer surface (102), a lateral surface (103) and an inner surface (101); the drug-carrying layer (3) comprising a drug carrier and an active drug (301); the outer surface (102), lateral surface (103) and inner surface (101) of the base (1) all being covered by the drug-carrying layer (3); the active drug (301) only being distributed on at least a portion of the areas of the drug-carrying layer (3) covering the outer surface (102) and lateral surface (103), and, in the depth direction of the at least portion of areas, the concentration of the active drug (301) at a side adjacent to the base (1) being greater than the concentration of the active drug (301) on a side furthest from the base (1), and an area of the drug-carrying layer (3) disposed at the inner surface (101) of the base (1) not containing the active drug (301). The drug eluting device has a relatively long active-drug release period, and has a relatively low risk of blood clots.
(FR)
La présente invention concerne un dispositif d'élution de médicament et son procédé de fabrication, le dispositif d'élution de médicament comprenant une base (1) et une couche de support de médicament (3); la base (1) comportant une surface externe (102), une surface latérale (103) et une surface interne (101); la couche de support de médicament (3) comprenant un support de médicament et un médicament actif (301); la surface externe (102), la surface latérale (103) et la surface interne (101) de la base (1) étant toutes recouvertes de la couche de support de médicament (3); le médicament actif (301) étant uniquement réparti sur au moins une portion des zones de la couche de support de médicament (3) recouvrant la surface externe (102) et la surface latérale (103), et, dans le sens de la profondeur desdites portions de zone, la concentration du médicament actif (301) au niveau d'un côté adjacent à la base (1) étant supérieure à la concentration du médicament actif (301) sur un côté le plus éloigné de la base (1), et une zone de la couche de support de médicament (3) disposée au niveau de la surface interne (101) de la base (1) ne contenant pas le médicament actif (301). Le dispositif d'élution de médicament présente une relativement longue période de libération active de médicament, et présente un relativement faible risque de formation de caillots sanguins.
(ZH)
一种药物洗脱器械及其制造方法,该药物洗脱器械包括基体(1)和载药层(3);基体(1)具有外表面(102)、侧表面(103)和内表面(101),载药层(3)含有药物载体和活性药物(301),基体(1)的外表面(102)、侧表面(103)和内表面(101)均被载药层(3)覆盖;活性药物(301)仅分布在载药层(3)的覆盖外表面(102)和侧表面(103)的至少部分区域,且在至少部分区域的厚度方向上,靠近基体(1)的一侧的活性药物(301)的浓度大于远离基体(1)的一侧的活性药物(301)的浓度,载药层(3)的位于基体(1)的内表面(101)的区域不含有活性药物(301)。该药物洗脱器械的活性药物(301)的释放周期较长,且血栓风险较低。
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