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1. WO2020133817 - IMMUNOLOGIC ADJUVANT COMPOSITION AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Publication Number WO/2020/133817
Publication Date 02.07.2020
International Application No. PCT/CN2019/083106
International Filing Date 17.04.2019
IPC
A61K 39/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 39/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
A61K 39/187 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
187Hog cholera virus
A61K 39/245 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
A61P 31/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
CPC
A61K 2039/5252
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5252inactivated (killed)
A61K 2039/5258
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5258Virus-like particles
A61K 2039/55511
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
A61K 2039/55577
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55577Saponins; Quil A; QS21; ISCOMS
A61K 39/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
A61K 39/0241
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
0241Mollicutes, e.g. Mycoplasma, Erysipelothrix
Applicants
  • 洛阳赛威生物科技有限公司 LUOYANG SEIWEI BIOTECHNOLOGIES CO., LTD. [CN]/[CN]
Inventors
  • 田克恭 TIAN, Kegong
  • 刘永梅 LIU, Yongmei
  • 张许科 ZHANG, Xuke
Agents
  • 北京华夏正合知识产权代理事务所(普通合伙) CHINA ZHENGHE INTELLECTUAL PROPERTY AGENCY
Priority Data
201811583863.024.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) IMMUNOLOGIC ADJUVANT COMPOSITION AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
(FR) COMPOSITION D'ADJUVANT IMMUNOLOGIQUE ET PROCÉDÉ POUR SA PRÉPARATION ET APPLICATION CORRESPONDANTE
(ZH) 一种免疫佐剂组合物及其制备方法和应用
Abstract
(EN)
The present invention provides an adjuvant composition, containing 0.2%-0.5%w/v of Carbomer, 0.1%-0.5% w/v of lecithin and 0.03%-0.2%w/v of ginsenoside. The adjuvant composition of the present invention not only guarantees vaccines to be clarified and/or stabilized for a long time but also effectively stimulates inactivated antigens and subunit antigens in the vaccines to generate high-titer antibody for immune protection. Inactivated vaccines or subunit vaccines prepared by the adjuvant composition according to the present invention can be used as diluents for freeze-dried live-virus antigens, and have no toxic action on live-virus antigens.
(FR)
La présente invention concerne une composition d'adjuvant, contenant 0,2 % à 0,5 % P/V de carbomère, 0,1 % à 0,5 % P/V de lécithine et 0,03 % à 0,2 % P/V de ginsénoside. La composition d'adjuvant de la présente invention garantit non seulement des vaccins clarifiés et/ou stables pendant une longue durée, mais stimule également efficacement des antigènes et des antigènes de sous-unités inactivés dans les vaccins pour générer un anticorps à titre élevé pour la protection immune. Des vaccins ou des vaccins à sous-unités inactivés préparés par la composition d'adjuvant selon la présente invention peuvent être utilisés en tant que diluants pour des antigènes de virus vivants lyophilisés et n'ont pas d'action toxique sur des antigènes de virus vivants.
(ZH)
本发明提供了一种佐剂组合物,该佐剂组合物含有0.2%-0.5%w/v卡波姆、0.1%-0.5%w/v卵磷脂、0.03%-0.2%w/v人参皂苷。本发明的佐剂组合物不仅能在保证疫苗长时期澄清和/或稳定;并且能有效激发其中的灭活抗原和亚单位抗原产生高滴度抗体,进行免疫保护。本发明的佐剂组合物其制备的灭活疫苗或亚单位疫苗可以用作冻干的活病毒抗原的稀释剂,对活病毒抗原无毒杀作用。
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