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1. WO2020133805 - PROBIOTIC MIXED FORMULATION HAVING ANTI-INFLUENZA CAPABILITY AND USE THEREOF

Publication Number WO/2020/133805
Publication Date 02.07.2020
International Application No. PCT/CN2019/082656
International Filing Date 15.04.2019
IPC
C12N 1/20 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
A23L 33/135 2016.1
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
135Bacteria or derivatives thereof, e.g. probiotics
A61P 31/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
A61K 35/745 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
745Bifidobacteria
A61K 35/747 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
747Lactobacilli, e.g. L. acidophilus or L. brevis
C12R 1/225 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C-C12Q75
1Microorganisms
01Bacteria or actinomycetales
225Lactobacillus
CPC
A23L 33/135
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
135Bacteria or derivatives thereof, e.g. probiotics
A23V 2002/00
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
2002Food compositions, function of food ingredients or processes for food or foodstuffs
A23Y 2220/00
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
YINDEXING SCHEME RELATING TO LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
2220Lactobacillus
A23Y 2300/29
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
YINDEXING SCHEME RELATING TO LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
2300Bifidobacterium
29Breve
A61K 2035/11
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
11Medicinal preparations comprising living procariotic cells
A61K 2035/115
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
11Medicinal preparations comprising living procariotic cells
115Probiotics
Applicants
  • 江南大学 JIANGNAN UNIVERSITY [CN]/[CN]
Inventors
  • 陈卫 CHEN, Wei
  • 陆文伟 LU, Wenwei
  • 翟齐啸 ZHAI, Qixiao
  • 刘馨阳 LIU, Xinyang
  • 赵建新 ZHAO, Jianxin
  • 杭锋 HANG, Feng
  • 张灏 ZHANG, Hao
Agents
  • 哈尔滨市阳光惠远知识产权代理有限公司 HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD.
Priority Data
201811598890.526.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PROBIOTIC MIXED FORMULATION HAVING ANTI-INFLUENZA CAPABILITY AND USE THEREOF
(FR) FORMULATION MIXTE PROBIOTIQUE AYANT DES VERTUS ANTI-GRIPPALES ET SON UTILISATION
(ZH) 一种具有抗流感能力的益生菌混合制剂及其应用
Abstract
(EN)
The present invention belongs to the technical field of microorganisms and the technical field of medicine, and a probiotic mixed formulation having anti-influenza capabilities and use thereof are disclosed. This probiotic mixed formulation has anti-influenza effects, specifically embodied in: (1) significantly alleviating the degree of weight loss of influenza mice; (2) significantly improving blood index of influenza mice; (3) significantly alleviating inflammation of respiratory tract infection of influenza mice; (4) significantly reducing lung viral load of influenza mice (namely, significantly inhibiting the replication and proliferation of an influenza virus in influenza mice); and (5) significantly increasing the expression amount of pulmonary antiviral protein MxA of influenza mice. Therefore, the probiotic mixed formulation has great application prospects in the preparation of products for the prevention and/or treatment of atopic dermatitis and even the prevention and/or treatment of influenza.
(FR)
La présente invention concerne une formulation mixte probiotique ayant des vertus anti-grippales et son utilisation. Cette formulation mixte probiotique a des vertus anti-grippales, particulièrement pour : (1) l'atténuation significative du degré de la perte de poids chez la souris infectée; (2) l'amélioration significative des indices sanguins chez la souris infectée; (3) l'atténuation significative de l'inflammation de l'infection des voies respiratoires chez la souris infectée; (4) la réduction significative de la charge virale pulmonaire chez la souris infectée (à savoir, l'inhibition significative de la réplication et de la prolifération d'un virus de la grippe chez la souris infectée); et (5) l'augmentation significative de la quantité d'expression de la protéine antivirale pulmonaire MxA chez la souris infectée. Par conséquent, la formulation mixte probiotique présente de grandes perspectives d'application dans la préparation de produits pour la prévention et/ou le traitement de la dermatite atopique et même la prévention et/ou le traitement de la grippe.
(ZH)
本发明公开了一种具有抗流感能力的益生菌混合制剂及其应用,属于微生物技术领域以及医药技术领域。此益生菌混合制剂具有抗流感的作用,具体体现在:(1)显著改善流感小鼠体重下降程度;(2)显著改善流感小鼠血液指标;(3)显著改善流感小鼠的呼吸道感染炎症状况;(4)显著降低流感小鼠肺部病毒载量(即显著抑制流感病毒在流感小鼠体内的复制、增值);(5)显著增强流感小鼠肺部抗病毒蛋白MxA的表达量,因此,此益生菌混合制剂在制备预防和/或治疗特应性皮炎乃至预防和/或治疗流感的产品中,具有巨大的应用前景。
Also published as
Latest bibliographic data on file with the International Bureau