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1. WO2020132781 - USE OF D-34 PROTEIN AND HEAT PROTECTANT CONTAINING D-34 PROTEIN

Publication Number WO/2020/132781
Publication Date 02.07.2020
International Application No. PCT/CN2018/122994
International Filing Date 24.12.2018
IPC
C07K 1/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
C12N 9/96 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
C12N 15/70 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
C07K 14/415 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
415from plants
CPC
C07K 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
C07K 14/415
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
415from plants
C12N 15/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
C12N 9/96
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Applicants
  • 深圳大学 SHENZHEN UNIVERSITY [CN]/[CN]
Inventors
  • 刘国宝 LIU, Guobao
  • 卜友达 BU, Youda
  • 孙亚军 SUN, Yajun
  • 刘昀 LIU, Yun
  • 李承娜 LI, Chengna
  • 郑易之 ZHENG, Yizhi
Agents
  • 深圳市恒申知识产权事务所(普通合伙) HENSEN INTELLECTUAL PROPERTY FIRM
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) USE OF D-34 PROTEIN AND HEAT PROTECTANT CONTAINING D-34 PROTEIN
(FR) UTILISATION D'UNE PROTÉINE D-34 ET D'UN AGENT DE PROTECTION THERMIQUE CONTENANT UNE PROTÉINE D-34
(ZH) D-34蛋白的应用和含有D-34蛋白的热保护剂
Abstract
(EN)
Disclosed is a use of D-34 protein as a heat stabilizer of at least one of a protein, an enzyme, an antibody and a cell. A heat protectant is used for the heat protection of at least one of a protein, enzyme, antibody and cell, and the heat protectant contains D-34 protein. The D-34 protein and the heat protectant can effectively protect the heat stability of a target protein, enzyme, antibody and cell, thereby effectively ensuring the biological activity of the target protein, enzyme and antibody and preventing the aggregation thereof, and same have the effect of protecting various proteins, enzymes and antibodies. Therefore, the D-34 protein and the heat protectant can also improve cellular heat tolerance and ensure the activity of a cell in a relatively high-temperature environment.
(FR)
L'invention concerne une utilisation de la protéine D-34 en tant que stabilisant thermique d'au moins l'une d'une protéine, d'une enzyme, d'un anticorps et d'une cellule. Un agent de protection thermique est utilisé pour la protection thermique d'au moins l'une d'une protéine, d'une enzyme, d'un anticorps et d'une cellule, et l'agent de protection thermique contient une protéine D-34. La protéine D-34 et l'agent de protection thermique peuvent protéger de manière efficace la stabilité thermique d'une protéine cible, d'une enzyme, d'un anticorps et d'une cellule, ce qui permet d'assurer de manière efficace l'activité biologique de la protéine cible, de l'enzyme et de l'anticorps et d'empêcher leur agrégation, et ont pour effet de protéger diverses protéines, enzymes et anticorps. Par conséquent, la protéine D-34 et l'agent de protection thermique peuvent également améliorer la tolérance à la chaleur cellulaire et assurer l'activité d'une cellule dans un environnement à température relativement élevée.
(ZH)
所述D-34蛋白作为蛋白、酶、抗体和细胞中至少一种的热稳定剂的应用。所述热保护剂用于蛋白、酶、抗体和细胞至少一种的热保护,其含有D-34蛋白。所述D-34蛋白和所述热保护剂能够有效保护目标蛋白、酶、抗体和细胞的热稳定性,从而有效保证了目标蛋白、酶、抗体的生物活性和避免其聚集,而且具有保护多种蛋白、酶、抗体的作用。因此,所述D-34蛋白和热保护剂也同时能提高细胞耐热性,保证细胞在相对高温环境中的活性。
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