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1. WO2020118265 - STAT3 TRANSCRIPTION FACTOR INHIBITORS AND METHODS OF USING THE SAME

Publication Number WO/2020/118265
Publication Date 11.06.2020
International Application No. PCT/US2019/065085
International Filing Date 06.12.2019
IPC
C07D 233/26 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
04having one double bond between ring members or between a ring member and a non-ring member
20with substituted hydrocarbon radicals, directly attached to ring carbon atoms
26Radicals substituted by carbon atoms having three bonds to hetero atoms
C07C 233/66 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
66having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
C07D 263/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
30having two or three double bonds between ring members or between ring members and non-ring members
32with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 263/57 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
54Benzoxazoles; Hydrogenated benzoxazoles
56with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
57Aryl or substituted aryl radicals
C07D 307/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
10with substituted hydrocarbon radicals attached to ring carbon atoms
16Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 307/54 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02not condensed with other rings
34having two or three double bonds between ring members or between ring members and non-ring members
38with substituted hydrocarbon radicals attached to ring carbon atoms
54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
CPC
C07C 205/43
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
205Compounds containing nitro groups bound to a carbon skeleton
39the carbon skeleton being further substituted by esterified hydroxy groups
42having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
43to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
C07C 233/66
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
66having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
C07C 235/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
42having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
44with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
58with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
64having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07D 233/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
04having one double bond between ring members or between a ring member and a non-ring member
20with substituted hydrocarbon radicals, directly attached to ring carbon atoms
26Radicals substituted by carbon atoms having three bonds to hetero atoms
C07D 263/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
30having two or three double bonds between ring members or between ring members and non-ring members
32with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 263/57
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
54Benzoxazoles; Hydrogenated benzoxazoles
56with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
57Aryl or substituted aryl radicals
Applicants
  • THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US]/[US]
  • REIGAN, Philip [GB]/[US]
  • BACKOS, Donald S. [US]/[US]
  • MATHESON, Christopher J. [GB]/[US]
  • FURTEK, Steffanie L. [US]/[US]
  • JORDAN, Craig T. [US]/[US]
  • AMAYA, Maria L. [US]/[US]
Inventors
  • REIGAN, Philip
  • BACKOS, Donald S.
  • MATHESON, Christopher J.
  • FURTEK, Steffanie L.
  • JORDAN, Craig T.
  • AMAYA, Maria L.
Agents
  • PAVAO, Matthew
  • SUN, Xixi
  • POWERS, Robert
Priority Data
62/776,69607.12.2018US
62/878,65525.07.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STAT3 TRANSCRIPTION FACTOR INHIBITORS AND METHODS OF USING THE SAME
(FR) INHIBITEURS DU FACTEUR DE TRANSCRIPTION STAT3 ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN)
Compounds that inhibit the activity of Signal transducer and activator of transcription 3 (STAT3), or pharmaceutically acceptable salts or prodrugs thereof, and methods of using these compounds to treat cancer and other diseases.
(FR)
L'invention concerne des composés qui inhibent l'activité du transducteur de signal et de l'activateur de transcription 3 (STAT3), ou des sels ou promédicaments pharmaceutiquement acceptables de ceux-ci, et des procédés d'utilisation de ces composés pour traiter le cancer et d'autres maladies.
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