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1. WO2020118259 - PROTEIN CRYSTAL ENGINEERING THROUGH DNA HYBRIDIZATION INTERACTIONS

Publication Number WO/2020/118259
Publication Date 11.06.2020
International Application No. PCT/US2019/065078
International Filing Date 06.12.2019
IPC
C30B 7/14 2006.01
CCHEMISTRY; METALLURGY
30CRYSTAL GROWTH
BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
7Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
14the crystallising materials being formed by chemical reactions in the solution
C07K 1/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
14Extraction; Separation; Purification
30by precipitation
C30B 29/58 2006.01
CCHEMISTRY; METALLURGY
30CRYSTAL GROWTH
BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
29Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
54Organic compounds
58Macromolecular compounds
B01D 9/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
9Crystallisation
CPC
B01D 9/0077
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
9Crystallisation
0077Screening for crystallisation conditions or for crystal forms
C07K 1/306
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
14Extraction; Separation; Purification
30by precipitation
306by crystallization
C30B 29/58
CCHEMISTRY; METALLURGY
30CRYSTAL GROWTH
BSINGLE-CRYSTAL-GROWTH
29Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
54Organic compounds
58Macromolecular compounds
C30B 7/14
CCHEMISTRY; METALLURGY
30CRYSTAL GROWTH
BSINGLE-CRYSTAL-GROWTH
7Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
14the crystallising materials being formed by chemical reactions in the solution
Applicants
  • NORTHWESTERN UNIVERSITY [US]/[US]
Inventors
  • MIRKIN, Chad, A.
  • MCMILLAN, Janet, R.
  • HAYES, Oliver, G.
  • WINEGAR, Peter, H.
Agents
  • ALLIKIAN, Michael, J.
  • DANEK, Shelley, C.
Priority Data
62/776,39906.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROTEIN CRYSTAL ENGINEERING THROUGH DNA HYBRIDIZATION INTERACTIONS
(FR) INGÉNIERIE DE CRISTAUX DE PROTÉINES PAR L'INTERMÉDIAIRE D'INTERACTIONS D'HYBRIDATION DE L'ADN
Abstract
(EN)
The present disclosure provides compositions comprising protein crystals and methods for programmable biomaterial synthesis. The methods of the disclosure provide the ability to organize proteins within protein crystals with control over protein orientation.
(FR)
La présente invention concerne des compositions comprenant des cristaux de protéines et des procédés de synthèse de biomatériau programmable. Les procédés selon l'invention permettent d'organiser des protéines à l'intérieur de cristaux de protéines avec une régulation de l'orientation des protéines.
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