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1. WO2020118250 - COMPOSITIONS THAT ENHANCE IRON ABSORPTION AND METHODS OF USE THEREOF

Publication Number WO/2020/118250
Publication Date 11.06.2020
International Application No. PCT/US2019/065063
International Filing Date 06.12.2019
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 3/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
CPC
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
02Nutrients, e.g. vitamins, minerals
C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
Applicants
  • UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED [US]/[US]
Inventors
  • VIDYASAGAR, Sadasivan
  • COLLINS, James
  • WOLOSHUN, Regina
Agents
  • FASH ENA, Sarah J.
Priority Data
62/776,64507.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS THAT ENHANCE IRON ABSORPTION AND METHODS OF USE THEREOF
(FR) COMPOSITIONS AMÉLIORANT L'ABSORPTION DU FER ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN)
Amino acid compositions useful for increasing the amount of the divalent metal-ion transporter 1, DMT1 (encoded by the gene SLC11A2), on the duodenal bmsh border membrane (BBM) are described herein. Methods for increasing the concentration of DMT 1 on the duodenal BBM (on trafficking) and increasing iron uptake are also presented. Compositions and methods described herein are useful for treating a disorder or disease associated with iron deficiency in subjects afflicted with such disorders or diseases. Use of these compositions for the treatment of disorders or diseases associated with iron deficiency and in the preparation of a medicament for the treatment of disorders or diseases associated with iron deficiency are also encompassed herein.
(FR)
L'invention concerne des compositions d'acides aminés utiles pour augmenter la quantité du transporteur métal-ion divalent 1, DMT1 (codé par le gène SLC11A2), sur la membrane de bordure bmsh duodénale (BBM). L'invention concerne également des procédés pour augmenter la concentration de DMT 1 sur le BBM duodénal (sur le trafic) et augmenter l'absorption du fer. Les compositions et les procédés de l'invention sont utiles pour traiter un trouble ou une maladie associé à une déficience en fer chez des sujets atteints de tels troubles ou maladies. L'invention concerne également l'utilisation de ces compositions pour le traitement de troubles ou de maladies associés à une carence en fer et dans la préparation d'un médicament pour le traitement de troubles ou de maladies associés à une déficience en fer.
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