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1. WO2020118216 - IDENTIFICATION AND TARGETING OF TUMOR PROMOTING CARCINOMA ASSOCIATED FIBROBLASTS FOR DIAGNOSIS AND TREATMENT OF CANCER AND OTHER DISEASES

Publication Number WO/2020/118216
Publication Date 11.06.2020
International Application No. PCT/US2019/065008
International Filing Date 06.12.2019
IPC
A61M 1/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
B01D 61/14 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
14Ultrafiltration; Microfiltration
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
CPC
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 47/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
B01D 61/14
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis, ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
14Ultrafiltration; Microfiltration
G01N 33/574
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
Applicants
  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US]/[US]
Inventors
  • KALLURI, Raghu
Agents
  • SCHNEPP, Amanda, S.J.
Priority Data
62/777,10108.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IDENTIFICATION AND TARGETING OF TUMOR PROMOTING CARCINOMA ASSOCIATED FIBROBLASTS FOR DIAGNOSIS AND TREATMENT OF CANCER AND OTHER DISEASES
(FR) IDENTIFICATION ET CIBLAGE DE FIBROBLASTES ASSOCIÉS AUX CARCINOMES FAVORISANT LES TUMEURS POUR LE DIAGNOSTIC ET LE TRAITEMENT DU CANCER ET D'AUTRES MALADIES
Abstract
(EN)
Provided herein are agents, such as antibodies or chimeric antigen receptors, that target TP-CAFs. Methods of treating cancer are provided, comprising administering to a patient in need thereof an effective amount of a TP-CAFs-neutralizing agent. The methods can further include administering an effective amount of chemotherapy or immunotherapy to said patient. The methods can include administering an IL-6 signaling inhibitor in combination with an immune checkpoint blockade therapy.
(FR)
L'invention concerne des agents, tels que des anticorps ou des récepteurs d'antigènes chimériques, qui ciblent les TP-CAF. L'invention concerne également des méthodes de traitement du cancer, comprenant l'administration, à un patient qui en a besoin, d'une quantité efficace d'un agent neutralisant les TP-CAF. Les méthodes peuvent en outre comprendre l'administration d'une quantité efficace de chimiothérapie ou d'immunothérapie audit patient. Les méthodes peuvent comprendre l'administration d'un inhibiteur de signalisation d'IL-6 en combinaison avec une thérapie de blocage de points de contrôle immunitaires.
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