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1. WO2020118183 - 2,4-DIAMINOPYRIMIDINE BICYCLES FOR TREATING CANCER

Publication Number WO/2020/118183
Publication Date 11.06.2020
International Application No. PCT/US2019/064937
International Filing Date 06.12.2019
IPC
A61K 31/444 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
444containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/506 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61K 31/517 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
CPC
A61K 31/444
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
444containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
A61K 31/506
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61K 31/517
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
Applicants
  • KAPOOR, Tarun M. [US]/[US]
  • CUPIDO, Tommaso [US]/[US]
  • PISA, Rudolf [US]/[US]
Inventors
  • KAPOOR, Tarun M.
  • CUPIDO, Tommaso
  • PISA, Rudolf
Agents
  • BOHNSTEDT, Adolph
Priority Data
62/776,17606.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 2,4-DIAMINOPYRIMIDINE BICYCLES FOR TREATING CANCER
(FR) BICYCLES DE 2,4-DIAMINOPYRIMIDINE POUR LE TRAITEMENT DU CANCER
Abstract
(EN)
A genus of quinazoline and pyrrolo[3,2-d]pyrimidine derivatives is disclosed. The compounds are of the genus (I). The compounds selectively inhibit subfamilies of AAA+ proteins and TrkA-C. They are useful in the treatment of Alzheimer's disease and as anticancer agents.
(FR)
L'invention concerne un genre de dérivés de quinazoline et de pyrrolo[3,2-d]pyrimidine. Les composés sont du genre (I). Les composés inhibent sélectivement les sous-familles de protéines AAA+ et TrkA-C. Ils sont utiles dans le traitement de la maladie d'Alzheimer et en tant qu'agents anticancéreux.
Latest bibliographic data on file with the International Bureau