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1. WO2020118179 - PEPTIDOMIMETIC INHIBITORS OF Β-CATENIN/TCF PROTEIN–PROTEIN INTERACTION

Publication Number WO/2020/118179
Publication Date 11.06.2020
International Application No. PCT/US2019/064929
International Filing Date 06.12.2019
IPC
C07D 403/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 413/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Applicants
  • H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US]/[US]
Inventors
  • JI, Haitao
Agents
  • JACKSON BECKFORD, Shirlene
  • CURFMAN, Christopher L.
  • HALL, Miles E.
Priority Data
62/776,72607.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PEPTIDOMIMETIC INHIBITORS OF Β-CATENIN/TCF PROTEIN–PROTEIN INTERACTION
(FR) INHIBITEURS PEPTIDOMIMÉTIQUES DE L'INTERACTION PROTÉINE-PROTÉINE B-CATÉNINE/TCF
Abstract
(EN)
Disclosed are inhibitors for the β-catenin/T-cell factor interaction. The inhibitors are selective for β-catenin/T-cell factor over β-catenin/phosphocadherin, and β- catenin/phosphoAPC interactions. Methods of using the disclosed compounds to treat cancer are also disclosed.
(FR)
L'invention concerne des inhibiteurs de l'interaction β-caténine/facteur de lymphocytes T. Les inhibiteurs sont sélectifs pour les interactions β-caténine/facteur des lymphocytes T de façon supérieure aux interactions β-caténine/phosphocadhérine et β-caténine/phosphoAPC. Des méthodes d'utilisation desdits composés pour le traitement du cancer sont également décrites.
Latest bibliographic data on file with the International Bureau