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1. WO2020118165 - SUBCUTANEOUS DELIVERY OF HIGH CONCENTRATION FORMULATIONS

Publication Number WO/2020/118165
Publication Date 11.06.2020
International Application No. PCT/US2019/064901
International Filing Date 06.12.2019
IPC
A61M 5/142 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
A61K 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
CPC
A61K 31/711
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
A61K 47/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/183
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
183Amino acids, e.g. glycine, EDTA or aspartame
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61K 9/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61M 2005/14252
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
14244adapted to be carried by the patient, e.g. portable on the body
14248of the skin patch type
14252with needle insertion means
Applicants
  • JAZZ PHARMACEUTICALS IRELAND LIMITED [IE]/[IE]
  • ENABLE INJECTIONS, INC. [US]/[US]
Inventors
  • DIMITROVA, Mariana
  • HUDDLESTON, Matthew J.
  • WANG, Qi
Agents
  • TUSCAN, Michael S.
  • FLECKENSTEIN, Anne E.
  • VEITENHEIMER, Erich
Priority Data
62/776,50007.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBCUTANEOUS DELIVERY OF HIGH CONCENTRATION FORMULATIONS
(FR) ADMINISTRATION SOUS-CUTANÉE DE FORMULATIONS À HAUTE CONCENTRATION
Abstract
(EN)
The present disclosure provides high concentration low viscosity defibrotide formulations administered via an automated injection device. The device is calibrated for optimum flow rate and administration of the high concentration low viscosity formulation.
(FR)
La présente invention concerne des formulations de défibrotide à faible viscosité et à haute concentration administrées par l'intermédiaire d'un dispositif d'injection automatisé. Le dispositif est étalonné pour un débit et une administration optimum de la formulation à faible viscosité et à haute concentration.
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