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1. WO2020118159 - METHODS AND COMPOSITIONS COMPRISING AN NFKB INHIBITOR AND AN ADJUVANT

Publication Number WO/2020/118159
Publication Date 11.06.2020
International Application No. PCT/US2019/064888
International Filing Date 06.12.2019
IPC
A61K 38/08 2019.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 31/05 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
Applicants
  • THE UNIVERSITY OF CHICAGO [US]/[US]
Inventors
  • ESSER-KAHN, Aaron
  • MOSER, Brittany
Agents
  • STELLMAN, Laurie Friesenhahn
Priority Data
62/776,86007.12.2018US
62/924,31522.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS COMPRISING AN NFKB INHIBITOR AND AN ADJUVANT
(FR) MÉTHODES ET COMPOSITIONS COMPORTANT UN INHIBITEUR DE NF-KB ET UN ADJUVANT
Abstract
(EN)
The current disclosure describes the use of NFkB inhibitors as immune potentiators in vaccine compositions comprising adjuvants. Accordingly, aspects of the disclosure relate to a method for vaccinating a subject comprising administering a NFkB inhibitor and an adjuvant (or a composition of the disclosure comprising NFkB and an adjuvant) to the subject. Further aspects relate to a method for inhibiting an inflammatory reaction associated with an adjuvant in a subject, the method comprising co-administering a NFkB inhibitor and an adjuvant (or a composition of the disclosure comprising NFkB and an adjuvant) to the subject. Yet further aspects relate to a pharmaceutical composition comprising a NFkB inhibitor and an adjuvant.
(FR)
La présente invention concerne l'utilisation d'inhibiteurs de NF-kB comme agents de potentialisation immunitaires dans des compositions vaccinales comportant des adjuvants. À cet égard, certains aspects de l'invention concernent une méthode de vaccination d'un sujet qui comprend l'administration au sujet d'un inhibiteur de NF-kB et d'un adjuvant (ou d'une composition selon l'invention comportant NF-kB et un adjuvant). D'autres aspects concernent un procédé d'inhibition de la réaction inflammatoire associée à un adjuvant chez un sujet, la méthode comprenant la co-administration au sujet d'un inhibiteur de NF-kB et d'un adjuvant (ou d'une composition selon l'invention comportant NF-kB et un adjuvant). Encore d'autres aspects concernent une composition pharmaceutique comportant un inhibiteur de NF-kB et un adjuvant.
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