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1. WO2020118106 - LATERAL LOADING OF MICROCAPILLARY ARRAYS

Publication Number WO/2020/118106
Publication Date 11.06.2020
International Application No. PCT/US2019/064774
International Filing Date 05.12.2019
IPC
B01J 19/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01L 3/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B81B 1/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
81MICROSTRUCTURAL TECHNOLOGY
BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
1Devices without movable or flexible elements, e.g. microcapillary devices
Applicants
  • XCELLA BIOSCIENCES, INC. [US]/[US]
Inventors
  • CHEN, Bob
  • TAN, Ming, X.
  • ESCAJEDA, Arturo, M.
Agents
  • MACDOUGALL, Christina, A.
  • GE, Xinquan
  • ESKER, Todd, W.
  • BALL, Conor, S.
  • ANTZZAK, Andrew
Priority Data
62/776,37406.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LATERAL LOADING OF MICROCAPILLARY ARRAYS
(FR) CHARGEMENT LATÉRAL DE RÉSEAUX DE MICROCAPILLAIRES
Abstract
(EN)
Lateral loading methods of use in high-throughput methods for screening large populations of variant proteins are provided. The methods utilize a flow cell encompassing large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules.
(FR)
L'invention concerne des procédés de chargement latéral destinés à être utilisés dans des procédés à haut rendement pour cribler de grandes populations de protéines variantes. Les procédés utilisent une cuve à circulation comprenant des réseaux de microcapillaires à grande échelle, chaque microcapillaire comprenant une solution contenant une protéine variante, une molécule cible immobilisée, et un élément rapporteur. Les molécules cibles immobilisées peuvent comprendre n'importe quelle molécule d'intérêt, notamment des protéines, des acides nucléiques, des glucides, et d'autres biomolécules.
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