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1. WO2020118103 - HEPARANASE INHIBITORS AND THEIR USE AS ANTI-CANCER COMPOUNDS

Publication Number WO/2020/118103
Publication Date 11.06.2020
International Application No. PCT/US2019/064771
International Filing Date 05.12.2019
IPC
A61K 31/7028 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
C07D 491/048 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
044with only one oxygen atom as ring hetero atom in the oxygen-containing ring
048the oxygen-containing ring being five-membered
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • WAYNE STATE UNIVERSITY [US]/[US]
  • TECHNION, ISRAEL INSTITUTE OF TECHNOLOGY [IL]/[IL]
  • UNIVERSITY OF IOWA RESEARCH FOUNDATION [US]/[US]
Inventors
  • NGUYEN, Hien M.
  • LOKA, Ravi
  • SLETTEN, Eric
  • VLODAVSKY, Israel
Agents
  • WINGER, C. Rachal
  • NGUYEN, Thu
  • HARDING, Tanya
  • BROWN, JR., Garry
Priority Data
62/775,80005.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HEPARANASE INHIBITORS AND THEIR USE AS ANTI-CANCER COMPOUNDS
(FR) INHIBITEURS D'HÉPARANASE ET LEUR UTILISATION COMME COMPOSÉS ANTICANCÉREUX
Abstract
(EN)
Anti-heparanase compounds for the treatment of cancer are described. The anti-heparanase compounds are high affinity, synthetic glycopolymers that result in minimal anticoagulant activity. Stereoselective fluorinated forms of these compounds are also provided.
(FR)
L'invention concerne des composés anti-héparanase pour le traitement du cancer. Les composés anti-héparanase sont des glycopolymères synthétiques, de haute affinité, qui conduisent à une activité anticoagulante minimale. L'invention concerne également des formes fluorées stéréosélectives de ces composés.
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