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1. WO2020118076 - REGULATABLE CELL SURFACE RECEPTORS AND RELATED COMPOSITIONS AND METHODS

Publication Number WO/2020/118076
Publication Date 11.06.2020
International Application No. PCT/US2019/064722
International Filing Date 05.12.2019
IPC
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 14/725 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
725T-cell receptors
Applicants
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US]
Inventors
  • MACKALL, Crystal
  • LABANIEH, Louai
  • MAJZNER, Robbie
  • LIN, Michael Z.
Agents
  • DAVY, Brian E.
Priority Data
62/776,25006.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REGULATABLE CELL SURFACE RECEPTORS AND RELATED COMPOSITIONS AND METHODS
(FR) RÉCEPTEURS DE SURFACE CELLULAIRE RÉGULABLES ET COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
Abstract
(EN)
Provided herein are cell surface receptors that include an extracellular binding domain, a transmembrane domain, an intracellular signaling domain, and a protease cleavage site disposed between the extracellular binding domain and the intracellular signaling domain. In certain aspects, the cell surface receptors are engineered cell surface receptors, such as chimeric antigen receptors (CARs). Also provided are cells that include such receptors (e.g., where the cells express the receptors on their surface) and pharmaceutical compositions including such cells. Nucleic acids that encode the cell surface receptors, cells including such nucleic acids, and pharmaceutical compositions including such cells, are also provided. Also provided are methods for regulating signaling of a cell surface receptor, and methods of using the cells of the present disclosure, including methods of using such cells to administer a regulatable cell-based therapy to an individual.
(FR)
L'invention concerne des récepteurs de surface cellulaire qui comprennent un domaine de liaison extracellulaire, un domaine transmembranaire, un domaine de signalisation intracellulaire et un site de clivage par les protéases disposé entre le domaine de liaison extracellulaire et le domaine de signalisation intracellulaire. Dans certains aspects, les récepteurs de surface cellulaire sont des récepteurs de surface cellulaire modifiés, tels que des récepteurs d'antigènes chimériques (CAR). L'invention concerne également des cellules comprenant de tels récepteurs (par exemple, des cellules exprimant les récepteurs sur leur surface) et des compositions pharmaceutiques comprenant de telles cellules. L'invention concerne également des acides nucléiques codant pour les récepteurs de surface cellulaire, des cellules comprenant de tels acides nucléiques, et des compositions pharmaceutiques comprenant de telles cellules. L'invention concerne en outre des procédés de régulation d'un récepteur de surface cellulaire, et des procédés d'utilisation des cellules de la présente invention, notamment des procédés d'utilisation de telles cellules pour administrer une thérapie à base de cellules régulables à un individu.
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