Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020118060 - NEUROACTIVE STEROIDS AND THEIR METHODS OF USE

Publication Number WO/2020/118060
Publication Date 11.06.2020
International Application No. PCT/US2019/064692
International Filing Date 05.12.2019
IPC
C07J 41/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
C07J 43/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
43Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopentahydrophenanthrene skeleton
A61K 31/58 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
A61K 31/57 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
A61K 31/575 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
C07J 41/0044
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
0033not covered by C07J41/0005
0044with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
C07J 41/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
0033not covered by C07J41/0005
005the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
C07J 41/0055
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
0033not covered by C07J41/0005
0055the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
C07J 41/0094
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
0033not covered by C07J41/0005
0094containing nitrile radicals, including thiocyanide radicals
C07J 43/003
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
43Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
003not condensed
Applicants
  • SAGE THERAPEUTICS, INC. [US]/[US]
Inventors
  • BLANCO-PILLADO, Maria, Jesus
  • SALITURO, Francesco, G.
  • MORINGSTAR, Marshall, Lee
Agents
  • UITTO, Olivia, D.
  • BRODOWSKI, Michael
  • BUCHMAN, Joshua, J.
  • SHOVON, Ashraf
  • ARGENTIERI, Steven, R.
Priority Data
62/775,47005.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEUROACTIVE STEROIDS AND THEIR METHODS OF USE
(FR) STÉROÏDES NEUROACTIFS ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN)
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R19, R5, R3a, R1a, R1b, R2a, R2b, R4a, R4b, R6a, R6b, R7a,R7b,R11a, R11b, R12a,R12b, R18, RD, and q are defined herein. L is selected from the group consisting of: wherein A indicates the point of attachment at C17 and wherein X is selected from the group consisting of -C(0)N(R55a)(R55b), -N(R55a)(R55b), -N(R55b)C(O)(R55a), and R55C wherein R55c is carbon-bound substituted or unsubstituted heteroaryl or substituted or unsubstituted aryl. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
(FR)
L'invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable de celui-ci, dans laquelle R1 9, R5, R3a, R1a, R1b, R2a, R2b, R4a, R4b, R6a, R6b, R7a,R7a,R7b,R11a, R11b, R12a,R12b, R18, RD et q sont définis dans la description. L est choisi dans le groupe constitué par : A indiquant le point de fixation en C17 et X étant choisi dans le groupe constitué par -C(0)N(R55a)(R55b), -N(R55a)(R55b), -N(R55b)C(O)(R55a) et R55C, R55c étant un hétéroaryle substitué ou non substitué lié au carbone ou un aryle substitué ou non substitué. L'invention concerne également des compositions pharmaceutiques comprenant le composé de formule (I) et des procédés d'utilisation des composés, par exemple, dans le traitement de troubles liés au SNC.
Latest bibliographic data on file with the International Bureau