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1. WO2020118046 - QUANTIFYING FOREIGN DNA IN LOW-VOLUME BLOOD SAMPLES USING SNP PROFILING

Publication Number WO/2020/118046
Publication Date 11.06.2020
International Application No. PCT/US2019/064670
International Filing Date 05.12.2019
IPC
C12Q 1/6851 2018.01
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6851Quantitative amplification
C12Q 1/6855 2018.01
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6853using modified primers or templates
6855Ligating adaptors
C12Q 1/6858 2018.01
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6858Allele-specific amplification
C12Q 1/686 2018.01
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction
G01N 33/50 2006.01
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01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G16B 20/10 2019.01
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16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
10Ploidy or copy number detection
CPC
C12Q 1/6806
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C12Q 1/6827
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68involving nucleic acids
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6827for detection of mutation or polymorphism
C12Q 1/6883
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/156
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2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G16B 20/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
10Ploidy or copy number detection
Applicants
  • WILLIAM MARSH RICE UNIVERSITY [US]/[US]
Inventors
  • ZHANG, David, Yu
  • CHEN, Xi
  • VEISEH, Omid
  • DAI, Peng
  • ZHANG, Kerou
Agents
  • SCHNEPP, Amanda, S.J.
Priority Data
62/775,67305.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) QUANTIFYING FOREIGN DNA IN LOW-VOLUME BLOOD SAMPLES USING SNP PROFILING
(FR) QUANTIFICATION D'ADN ÉTRANGER DANS DES ÉCHANTILLONS DE SANG À FAIBLE VOLUME À L'AIDE D'UN PROFILAGE SNP
Abstract
(EN)
Provided herein are methods for quantifying foreign cell-free DNA (cfDNA) via SNP profiling of low-volume blood sample. The methods allow for monitoring the status of organ transplant rejection through analysis of small volumes of patient capillary blood samples collected non-invasively with fingersticks or other devices. The methods also allow for guiding the dosage of immunosuppressant and for preparing for a new organ transplant in case of imminent organ failure.
(FR)
L'invention concerne des procédés de quantification d'ADN acellulaire étranger (cfDNA) par génotypage SNP d'un échantillon de sang à faible volume. Les procédés permettent de surveiller l'état d'un rejet de greffe d'organe par l'analyse de petits volumes d'échantillons de sang capillaire de patient prélevés de manière non invasive avec des dispositifs de ponction capillaire ou d'autres dispositifs. Les procédés permettent également de guider le dosage du traitement immunosuppresseur et de préparer une nouvelle greffe d'organe en cas de défaillance imminente de l'organe.
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