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1. WO2020118035 - METHODS AND COMPOSITIONS FOR THE TREATMENT OF SENGERS SYNDROME

Publication Number WO/2020/118035
Publication Date 11.06.2020
International Application No. PCT/US2019/064651
International Filing Date 05.12.2019
IPC
A61K 38/07 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
07Tetrapeptides
A61P 9/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 9/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
A61P 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
08Vasodilators for multiple indications
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 9/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
Applicants
  • STEALTH BIOTHERAPEUTICS CORP [MC]/[MC]
Inventors
  • CARR, James
  • DIMATTEO, Michael
  • ABBRUSCATO, Anthony
  • BJORNSSON, Hans
Agents
  • EWING, James F.
  • HAYS, Rebecca, L.
  • COLLINS, Lisamarie, A.
Priority Data
62/776,38106.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR THE TREATMENT OF SENGERS SYNDROME
(FR) PROCÉDÉS ET COMPOSITIONS DESTINÉS AU TRAITEMENT DU SYNDROME DE SENGERS
Abstract
(EN)
The disclosure provides methods of preventing or treating Sengers syndrome in a mammalian subject, reducing risk factors associated with Sengers syndrome, and/or reducing the likelihood or severity of Sengers syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of AGK in subjects in need thereof.
(FR)
L'invention concerne des méthodes de prévention ou de traitement d'un syndrome de Sengers chez un sujet mammifère, de réduction des facteurs de risque associés au syndrome de Sengers, et/ou de réduction de la probabilité ou de la gravité d'un syndrome de Sengers. Les procédés comprennent l'administration au sujet d'une quantité efficace d'un peptide aromatique-cationique pour augmenter l'expression de AGK chez des sujets le nécessitant.
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