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1. WO2020117945 - SYNTHETIC DERIVATIVES OF CHOLIC ACID 7-SULFATE AND USES THEREOF

Publication Number WO/2020/117945
Publication Date 11.06.2020
International Application No. PCT/US2019/064488
International Filing Date 04.12.2019
IPC
A61K 31/575 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
C07J 9/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
9Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
CPC
A61K 31/575
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
575substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
C07J 9/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
9Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Applicants
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]/[US]
  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US]/[US]
Inventors
  • DEVLIN, Abigail Sloan
  • CHAUDHARI, Snehal, N.
  • SHEU, Eric Garland
  • HARRIS, David A.
  • LEE, Jinbo
Agents
  • BAKER, C., Hunter
  • ALAM, Saad
  • AMUNDSEN, Eric, L.
  • ATTISHA, Michael, J.
  • BALICH, Jason, W.
Priority Data
62/775,02904.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHETIC DERIVATIVES OF CHOLIC ACID 7-SULFATE AND USES THEREOF
(FR) DÉRIVÉS SYNTHÉTIQUES DU 7-SULFATE D'ACIDE CHOLIQUE ET UTILISATIONS DE CEUX-CI
Abstract
(EN)
The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), or an inflammatory disease (e.g., Crohn's disease, inflammatory bowel disease, ulcerative colitis, pancreatitis, hepatitis, appendicitis, gastritis, diverticulitis, celiac disease, food intolerance, enteritis, ulcer, gastroesophageal reflux disease (GERD), psoriatic arthritis, psoriasis, and rheumatoid arthritis) in a subject in need thereof comprising administering to a subject a compound of Formulae (I)-(XVII).
(FR)
Les compositions et les méthodes de l'invention sont liées, en partie, à la découverte que le 7-sulfate d'acide cholique pouvait être utilisé comme traitement du diabète. La présente invention concerne une méthode de traitement d'un trouble métabolique (par exemple le diabète, l'obésité), ou d'une maladie inflammatoire (par exemple la maladie de Crohn, la maladie inflammatoire intestinale, la rectocolite hémorragique, la pancréatite, l'hépatite, l'appendicite, la gastrite, la diverticulite, la maladie cœliaque, l'intolérance alimentaire, l'entérite, l'ulcère, le reflux gastro-œsophagien pathologique (RGOP), l'arthrite psoriasique, le psoriasis et la polyarthrite rhumatoïde) chez le patient qui en a besoin, ledit traitement comprenant l'administration au patient d'un composé représenté par les formules (I) à (XVII).
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