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1. WO2020117929 - METHODS AND COMPOSITIONS FOR TREATING ASTHMA

Publication Number WO/2020/117929
Publication Date 11.06.2020
International Application No. PCT/US2019/064458
International Filing Date 04.12.2019
IPC
C07K 16/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C12N 15/113 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Applicants
  • THE CHILDREN'S MEDICAL CENTER CORPORATION [US]/[US]
Inventors
  • CHATILA, Talal Amine
  • HARB, Hani
  • ESTY, Brittany
  • PHIPATANAKUL, Wanda
  • BARTNIKAS, Lisa M.
Agents
  • RESNICK, David S.
  • EISENSTEIN, Ronald I.
  • FITZGERALD, Mark J.
  • BENN, Susanna C.
  • BRAICH, Ravinderjit S.
  • CROSBY, David F.
  • HUFF, Shayne Y.
  • PTASHKA, Teresa A.
  • KLING, Nicole D.
Priority Data
62/775,12704.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR TREATING ASTHMA
(FR) MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE L'ASTHME
Abstract
(EN)
Described herein are methods and compositions for treating asthma. Aspects of the invention relates to administering to a subject an agent that inhibits IL-6 signaling. Another aspect of the invention relates to administering the anti-IL-6R antibody, tocilizumab, to a subject in need thereof.
(FR)
La présente invention concerne des méthodes et des compositions pour le traitement de l'asthme. Certains aspects de l'invention consistent à administrer à un sujet un agent qui inhibe la signalisation IL-6. Un autre aspect de l'invention concerne l'administration de l'anticorps anti-IL-6 R, du tocilizumab, à un sujet en ayant besoin.
Latest bibliographic data on file with the International Bureau