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1. WO2020117886 - METHODS OF INHIBITING OSTEOCLASTOGENESIS AND OSTEOCLAST ACTIVITY

Publication Number WO/2020/117886
Publication Date 11.06.2020
International Application No. PCT/US2019/064372
International Filing Date 04.12.2019
IPC
A61K 31/428 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
428condensed with carbocyclic rings
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61K 31/428
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
428condensed with carbocyclic rings
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • VTV THERAPEUTICS LLC [US]/[US]
Inventors
  • ATTUCKS, Otis, Clinton
Agents
  • ROLLINS, Samuel, B.
Priority Data
62/776,54007.12.2018US
62/793,18116.01.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF INHIBITING OSTEOCLASTOGENESIS AND OSTEOCLAST ACTIVITY
(FR) MÉTHODES D'INHIBITION DE L'OSTÉOCLASTOGENESE ET DE L'ACTIVITÉ DES OSTÉOCLASTES
Abstract
(EN)
The present invention provides methods of inhibiting osteoclastogenesis or inhibiting osteoclast activity using fused imidazole derivative compounds and pharmaceutical compositions. These methods may be used to treat various bone destructive disorders.
(FR)
La présente invention concerne des procédés d'inhibition de l'ostéoclastogenèse ou d'inhibition de l'activité des ostéoclastes à l'aide de composés dérivés d'imidazole fusionnés et de compositions pharmaceutiques. Ces procédés peuvent être utilisés pour traiter divers troubles d'ostéolyse.
Latest bibliographic data on file with the International Bureau