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1. WO2020117867 - DARINAPARSIN AND RETINOIC ACID COMPOUNDS FOR TREATMENT OF IDH-ASSOCIATED DISORDERS

Publication Number WO/2020/117867
Publication Date 11.06.2020
International Application No. PCT/US2019/064326
International Filing Date 03.12.2019
IPC
A61K 31/203 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
203Retinoic acids
A61K 31/285 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
28Compounds containing heavy metals
285Arsenic compounds
A61K 33/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
36Arsenic; Compounds thereof
A61P 35/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07F 9/70 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
66Arsenic compounds
70Organo-arsenic compounds
C07F 9/72 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
66Arsenic compounds
70Organo-arsenic compounds
72Aliphatic compounds
Applicants
  • BETH ISRAEL-DEACONESS MEDICAL CENTER, INC. [US]/[US]
Inventors
  • PANDOLFI, Pier Paolo
  • CLOHESSY, John
  • MUGONI, Vera
  • CHEN, Ming
  • CHELONI, Giulia
Agents
  • BIEKER-BRADY, Kristina
Priority Data
62/774,70903.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DARINAPARSIN AND RETINOIC ACID COMPOUNDS FOR TREATMENT OF IDH-ASSOCIATED DISORDERS
(FR) DARINAPARSINE ET COMPOSÉS D'ACIDE RÉTINOÏQUE POUR LE TRAITEMENT DE TROUBLES ASSOCIÉS À L'IDH
Abstract
(EN)
The present invention features methods and kits relating to the treatment of mIDH1 leukemia, mIDH2 leukemia, and mIDH-associated solid tumors by administering Darinaparsin, a retinoic acid compound, or a combination of an arsenic compound and a retinoic acid compound.
(FR)
La présente invention concerne des méthodes et des kits se rapportant au traitement de la leucémie mIDH1, la leucémie mIDH2 et de tumeurs solides associées à mIDH par l'administration de darinaparsine, d'un composé d'acide rétinoïque ou d'une association d'un composé d'arsenic et d'un composé d'acide rétinoïque.
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