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1. WO2020117861 - AMPA RECEPTOR ANTAGONISTS SPECIFIC FOR CALCIUM PERMEABLE AMPA RECEPTORS AND METHODS OF TREATMENT THEREWITH

Publication Number WO/2020/117861
Publication Date 11.06.2020
International Application No. PCT/US2019/064318
International Filing Date 03.12.2019
IPC
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
Applicants
  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US]/[US]
Inventors
  • JENSEN, Frances
Agents
  • COHEN, Mark
  • PEARL COHEN ZEDEK LATZER BARATZ LLP
Priority Data
62/774,76103.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AMPA RECEPTOR ANTAGONISTS SPECIFIC FOR CALCIUM PERMEABLE AMPA RECEPTORS AND METHODS OF TREATMENT THEREWITH
(FR) ANTAGONISTES DE RÉCEPTEUR AMPA SPÉCIFIQUES DES RÉCEPTEURS AMPA PERMÉABLES AU CALCIUM ET PROCÉDÉS DE TRAITEMENT ASSOCIÉS
Abstract
(EN)
Antagonists that are specific for calcium permeable AMPA subtype glutamate receptors (CP-AMPARs) which lack the GluA2 subunit and methods utilizing the specific AMPA receptor antagonists to treat disorders and diseases having enhanced CP-AMPAR function or expression.
(FR)
La présente invention concerne des antagonistes qui sont spécifiques des récepteurs du glutamate de sous-type AMPA perméables au calcium (CP-AMPAR) qui ne comportent pas la sous-unité GluA2 et des procédés utilisant les antagonistes du récepteur AMPA spécifiques pour traiter des troubles et des maladies ayant une fonction ou une expression augmentée de CP-AMPAR.
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