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1. WO2020117853 - METHODS OF MAKING THERAPEUTIC T LYMPHOCYTES

Publication Number WO/2020/117853
Publication Date 11.06.2020
International Application No. PCT/US2019/064305
International Filing Date 03.12.2019
IPC
C12N 5/0783 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • NANTOMICS, LLC [US]/[US]
Inventors
  • NGUYEN, Andrew
  • SANBORN, John, Zachary
  • BENZ, Stephen, Charles
  • RABIZADEH, Sharooz
Agents
  • FESSENMAIER, Martin
  • PHUKAN, Priti, D.
  • DEAN, Ryan
  • BALLEW CHANG, Nicole
Priority Data
62/775,32304.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF MAKING THERAPEUTIC T LYMPHOCYTES
(FR) PROCÉDÉS DE PRODUCTION DE LYMPHOCYTES T THÉRAPEUTIQUES
Abstract
(EN)
Therapeutic T cells can be prepared from a population of TILs (tumor infiltrating lymphocytes) using tumor and patient- specific neoantigens expressed in antigen presenting cells to select for tumor reactive T cells. Selected tumor reactive T cells are then expanded and administered to the patient.
(FR)
Lymphocytes T thérapeutiques pouvant être préparés à partir d'une population de TIL (lymphocytes infiltrant les tumeurs) à l'aide de néo-antigènes spécifiques aux tumeurs et spécifiques au patient exprimés dans des cellules présentatrices de l'antigène afin de sélectionner des lymphocytes T réactifs aux tumeurs. Les lymphocytes T réactifs aux tumeurs sélectionnés sont ensuite multipliés et administrés au patient.
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