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1. WO2020117795 - ASSESSMENT AND MONITORING OF MUCOSAL HEALING IN CHILDREN AND ADULTS WITH CROHN'S DISEASE

Publication Number WO/2020/117795
Publication Date 11.06.2020
International Application No. PCT/US2019/064224
International Filing Date 03.12.2019
IPC
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 33/567 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
566using specific carrier or receptor proteins as ligand binding reagent
567utilising isolate of tissue or organ as binding agent
G01N 33/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
G06F 11/30 2006.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
FELECTRIC DIGITAL DATA PROCESSING
11Error detection; Error correction; Monitoring
30Monitoring
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G06F 7/60 2006.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
FELECTRIC DIGITAL DATA PROCESSING
7Methods or arrangements for processing data by operating upon the order or content of the data handled
60Methods or arrangements for performing computations using a digital non-denominational number representation, i.e. number representation without radix; Computing devices using combinations of denominational and non-denominational quantity representations
Applicants
  • PROMETHEUS BIOSCIENCES, INC. [US]/[US]
Inventors
  • MIMMS, Larry
  • JAIN, Anjali
Agents
  • BRESNAHAN, Matthew J.
Priority Data
62/775,03904.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ASSESSMENT AND MONITORING OF MUCOSAL HEALING IN CHILDREN AND ADULTS WITH CROHN'S DISEASE
(FR) ÉVALUATION ET SURVEILLANCE DE LA CICATRISATION DES MUQUEUSES CHEZ LES ENFANTS ET LES ADULTES ATTEINTS DE LA MALADIE DE CROHN
Abstract
(EN)
Provided are methods for assessing or monitoring mucosal healing in an adult or pediatric patient with Crohn's Disease (CD). Some embodiments include receiving or detecting levels of biomarkers. In some embodiments, the biomarkers include Ang1, Ang2, CEACAM1, VCAM1, TGFα, CRP, SAA1, MMP-1, MMP-2, MMP-3, MMP-9, EMMPRIN, or IL-7. Some embodiments include applying a mathematical algorithm to the biomarker levels to produce a Endoscopic Healing Index (EHI) score for the adult or pediatric patient.
(FR)
L'invention concerne des méthodes d'évaluation ou de surveillance de la cicatrisation des muqueuses chez un patient adulte ou pédiatrique atteint de la maladie de Crohn (CD). Certains modes de réalisation comprennent la réception ou la détection de niveaux de biomarqueurs. Dans certains modes de réalisation, les biomarqueurs comprennent Ang1, Ang2, CEACAM1, VCAM1, TGFα, CRP, SAA1, MMP -1, MMP -2, MMP -3, MMP -9, EMMPRIN, ou IL -7. Certains modes de réalisation comprennent l'application d'un algorithme mathématique aux niveaux de biomarqueurs afin de produire un score d'indice de cicatrisation endoscopique (EHI) pour le patient adulte ou pédiatrique.
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